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Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
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A. Basics
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01. History of Cardiology
02. Clinical Skills
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05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
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21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
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30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
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Compensatory mechanisms of gene regulation in response to chronic stress
Session:
CO - Prémio Jovem Investigador (Investigação Básica)
Speaker:
Isabel Campos
Congress:
CPC 2019
Topic:
O. Basic Science
Theme:
36. Basic Science
Subtheme:
36.2 Basic Science - Cardiac Biology and Physiology
Session Type:
Comunicações Orais
FP Number:
---
Authors:
Isabel Durães Campos; Marta Laranjo; Sofia Neves; Fernanda Marques; Nuno Sousa; Cátia Costa Oliveira; Catarina Vieira; Vitor Hugo Pereira
Abstract
<p>Introduction: Cardiovascular diseases are the major cause of death worldwide. Classical risk factors such as diabetes mellitus, arterial hypertension and smoking are recognised for their role in these diseases. However, other risk factors are now being considered like psychological stressand depression. One of the mechanisms underlying this association may be the mal-adaptive response to stressthat disrupts the hypothalamus-hypophysis-adrenal axis, the renin-angiotensin-aldosterone system and the sympathetic nervous system.</p> <p>Purpose: To evaluate the impact of chronic stress on the genetic expression of molecules involved in the adrenergic and catecholaminergic pathways in the myocardium.</p> <p>Methods: Eighteen adult male rats were randomly distributed in two groups: a control group and a group submitted to chronic mild stress protocol(CMS). This protocol consists of a sequential and random application of various stress factors (food deprivation, water deprivation, damp bedding, sloped box, light-dark rhythm alteration and confinement to a restricted space), during 4 consecutive weeks. After this period, all the animals were sacrificed and the left ventricle apex was collected and dissected. The expression of NPY, TH, GRK2, GRK5, β1AR, β2AR, β3AR and α1AR (adrenergic pathway) and acetylcholinesterase and VIP and M2ACh muscarinic receptors (catecholaminergic pathway) was quantified using real time-PCR.</p> <p>Results: GK2 had a median genetic expression superior in animals subjected to chronic mild stressprotocol [Mdn=0,040762 (0,036941-0,064620)] compared to the one found in the control group [Mdn=0,011624 (0,001181-0,031060)] (U=18,0; Z=-1,99; p=0,05; r=0,47). There were no significant differences found in the other proteins studied.</p> <p>Conclusion: The genetic expression of GRK2in stressed animals is superior comparing to the control group, which represents an attempt to desensitize adrenergic receptors. This may imply a compensatory mechanism in response to an excessive catecholaminergic stimulus triggered by chronic stress.</p>
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