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Diabetes Mellitus influence in Lipoprotein(A) gene expression and association to coronary artery disease
Session:
Sessão de Posters 10 - Dislipidémia e metabolismo lipídico
Speaker:
Ana Débora Câmara de Sá
Congress:
CPC 2024
Topic:
J. Preventive Cardiology
Theme:
28. Risk Factors and Prevention
Subtheme:
28.14 Risk Factors and Prevention - Other
Session Type:
Cartazes
FP Number:
---
Authors:
Ana Débora Câmara De Sá; M.I. Mendonça; F. Sousa; E. Henriques; S. Freitas; M. Rodrigues; S. Borges; G. Guerra; G. Abreu; A. Drumond; A.C. Sousa; R. Palma Dos Reis
Abstract
<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Introduction</strong>: Lipoprotein(a) [Lp(a)] and type 2 diabetes mellitus are both well-established risk factors for the development of coronary artery disease. Lp(a) levels are 75% to 95% heritable and predominately determined by single-nucleotide variants at the LPA gene; rs3798220 is one of the most studied variants and contributes significantly to Lp(a) levels. Whether diabetes could influence the LPA rs3798220 account for Lp(a) levels is unknown. </span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Goal</strong>: Assess differences in the association between the LPA rs3798220 T>C polymorphism and Lp(a) levels concerning coronary artery disease (CAD) in diabetic and non-diabetic populations</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Methods</strong>: A cohort of 3,209 subjects (mean age 59.3±8.9 years, 76.3% male) were selected from the the Research Center's dataset. The LPA rs3798220 T>C was genotyped with the TaqMan PCR assay (Applied Biosystems 7300 Real-Time). <span style="background-color:white"><span style="color:black">This genetic variant has a minor allele frequency (MAF) <2%; hence, the risk homozygous CC is a rare genotype, and we used the heterozygous CT in our analysis</span></span>. Lp(a) biochemical levels were measured in all participants. Of the 3,209 participants, 810 had diabetes, while 2,399 were non-diabetic. For each group, chi-squared tests were used to determine the association of CAD prevalence by genotype, and t-tests were used to evaluate differences in CAD prevalence by Lp(a) levels. </span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Results: </strong>In non-diabetic subjects, LPA TC was significantly associated with CAD compared with TT (p<0.0001); in the same way, Lp(a) was higher in the CAD population (37.2±39.7) compared to the healthy population (25.6±30.0) (p<0.0001). In diabetic individuals, Lp(a) is higher in the CAD population (38.5±41.4) compared to the population without CAD (23.9±29.2) (p<0.0001); nevertheless, there was no difference in genotype between CAD and non-CAD patients (p=0.710). </span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Conclusion: </strong>In non-diabetic patients, the LPA rs3798220 T>C variant appears to explain elevated Lp(a) levels and their association with CAD. However, in people with diabetes, Lp(a) is elevated in CAD patients besides the fact that no significant genotype differences were displayed. Non-genetic influences like behavioural factors or epigenetic changes may account for high Lp(a) levels in this population. </span></span></p>
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