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CPC 2018
CPC 2019
Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
CPC 2020
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0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
G. Aortic Disease, Peripheral Vascular Disease, Stroke
H. Interventional Cardiology and Cardiovascular Surgery
I. Hypertension
J. Preventive Cardiology
K. Cardiovascular Disease In Special Populations
L. Cardiovascular Pharmacology
M. Cardiovascular Nursing
N. E-Cardiology / Digital Health, Public Health, Health Economics, Research Methodology
O. Basic Science
P. Other
0 Themes
01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
37. Miscellanea
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Abstract
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Imaging phenotypes of left-dominant arrhythmogenic cardiomyopathy and dilated cardiomyopathy – a comparative magnetic resonance study
Session:
Posters 4 - Écran 10 - Miocárdio e Pericárdio
Speaker:
João Bicho Augusto
Congress:
CPC 2018
Topic:
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
Theme:
17. Myocardial Disease
Subtheme:
17.3 Myocardial Disease – Diagnostic Methods
Session Type:
Posters
FP Number:
---
Authors:
João Bicho Augusto; Rocío Eiros; Thomas Treibel; Gaby Captur; Mohammed Majid Akhtar; Alexandros Protonotarios; Thomas Gkosios; Konstantinos Savvatis; Saidi Mohiddin; James Moon; Perry Elliott; Luís Lopes
Abstract
<p><strong>Background: </strong>Emerging data have illustrated the diversity of genetic causes of arrhythmogenic cardiomyopathy (AC) with dominant LV involvement (ALVC). The relation between genotype and clinical phenotype is scarce and there are no systematic studies examining imaging phenotypes using cardiac magnetic resonance (CMR).</p> <p><strong>Objective: </strong>To identify phenotypic traits that distinguish ALVC from other genetic causes of dilated cardiomyopathy (DCM).</p> <p><strong>Methods: </strong>CMR data acquired for 30 patients (pts) with confirmed ALVC / DCM associated mutations in desmoplakin (<em>DSP</em>), filamin C (<em>FLNC</em>), lamin A/C (<em>LMNA</em>), titin (<em>TTN</em>) and <em>BAG3</em> were retrospectively re-analysed and compared on the basis of different individual genes and when grouped as ALVC (DSP / FLNC) vs DCM (others).</p> <p><strong>Results: </strong>Causal genes included DSP (n=11), FLNC (n=4), lamin A/C (n=6), BAG3 (n=4), titin (n=5). A comparison of clinical and imaging features is presented in Table 1. Figure 1 shows a comparison of late gadolinium enhancement patterns between different genes.</p> <p><strong>Conclusions</strong> Patients with genetic causes of ALVC have a higher burden of myocardial scar, in a more often sub-epicardial and ring-shaped pattern, in contrast with a more discrete midwall septal late gadolinium enhancement in other genetic causes of DCM. Other imaging parameters, including LV and RV sizes and function were similar.</p>
Slides
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