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The C825T genetic variant of the G Protein ß3 subunit is associated with Essential Hypertension in individuals with a family history of Essential Hypertension
Session:
Comunicações Orais - Sessão 07 - Genética em Cardiologia
Speaker:
Carolina Carvalhinha
Congress:
CPC 2024
Topic:
O. Basic Science
Theme:
36. Basic Science
Subtheme:
36.6 Basic Science - Other
Session Type:
Comunicações Orais
FP Number:
---
Authors:
Carolina Isabel Carvalhinha; Ana Célia Sousa; André Ferreira; Carolina Henriques; Francisco Barreto; Rui Fernandes; Mariana Rodrigues; Graça Guerra; Sofia Borges; Maria João Oliveira; Maria Isabel Mendonça; Roberto Palma Dos Reis
Abstract
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Introduction: </strong>Essential Hypertension (EH) is a risk factor for cardiovascular disease. Several studies </span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">indicate that the presence of a family history of EH leads to a greater risk of developing </span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">hypertension. Environmental and genetic factors interfere and increase this risk. </span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">However, it is not established which genetic polymorphisms are associated with the </span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">development of EH in individuals with familial EH.</span></span></p> <p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Objective:</strong> To study w</span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">hether the genetic variant of the G Protein C825T Subunit β3 is associated with </span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Essential Hypertension in individuals with a family history of EH.</span></span></p> <p><strong><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Methods: </span></span></strong><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">With a population of 1712 individuals: 627 individuals had a family history of </span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">hypertension and 1085 did not. Within the group of individuals with familial EH, a case-</span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">control study was carried out depending on whether they had EH (n=409) or not </span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">(n=218). All collected blood for biochemical analyzes and DNA collection for genetic </span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">analysis. We evaluated the frequency of the C825T G Protein Subunit β3 gene in the </span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">groups of hypertensive individuals with and without familial history of EH. We </span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">calculated the odds ratio (OR) to assess the risk of having EH conferred by the C825T G </span></span><span style="font-size:11.0pt"><span style="font-family:"Calibri",sans-serif">Protein </span></span><span style="font-size:11.0pt"><span style="font-family:"Calibri",sans-serif">β</span></span><span style="font-size:11.0pt"><span style="font-family:"Calibri",sans-serif">3 Subunit gene in individuals with familial history of EH.</span></span></p> <p><strong><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Results: </span></span></strong><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Our results indicate that the G Protein C825T Subunit β3 gene, in the dominant model, </span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">is associated with EH in individuals with familial history of EH (OR = 1.481; 95% CI: </span></span><span style="font-size:11.0pt"><span style="font-family:"Calibri",sans-serif">1.053-2.082; p=0.024).</span></span></p> <p><strong><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Conclusion: </span></span></strong><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">In our work, we concluded that individuals with familial history of EH and the CT+TT </span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">genotype of the G Protein C825T Subunit β3 have a higher risk of developing EH. </span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">These individuals should have greater intervention in controlling environmental risk </span></span><span style="font-size:11.0pt"><span style="font-family:"Calibri",sans-serif">factors to avoid developing hypertension.</span></span></p>
Slides
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