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Impact of acute culprit occlusion in patients presenting with non-ST segment elevation myocardial infarction
Session:
Sessão de Posters 51 - Enfarte agudo do miocárdio sem supra ST
Speaker:
Mafalda Griné
Congress:
CPC 2024
Topic:
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
Theme:
13. Acute Coronary Syndromes
Subtheme:
13.4 Acute Coronary Syndromes – Treatment
Session Type:
Cartazes
FP Number:
---
Authors:
Mafalda Griné; João Borges-Rosa; Gonçalo Terleira Batista; Tomás Carlos; Bernardo Resende; Ana Luísa Gomes Rocha; Manuel Oliveira-Santos; Lino Gonçalves
Abstract
<p style="text-align:start"><span style="font-size:medium"><span style="background-color:white"><span style="font-family:"Times New Roman",serif"><span style="color:#000000"><strong><span style="color:black">Introduction:</span></strong><span style="color:black"> There is acute coronary occlusion beyond the ST-segment elevation myocardial infarction (STEMI) criteria. Around 15-30% of patients presenting without significant ST-segment elevation have an occluded culprit in the coronary angiography. The clinical impact of these missed diagnoses remains unclear. We sought to evaluate the one-year outcomes of this subset of patients.</span></span></span></span></span></p> <p style="text-align:justify"><span style="font-size:medium"><span style="background-color:white"><span style="font-family:"Times New Roman",serif"><span style="color:#000000"><strong><span style="color:black">Methods:</span></strong> <span style="color:black">Retrospective analysis of consecutive patients admitted to our centre between January 2016 and November 2022 with a diagnosis of myocardial infarction. Those without follow-up data were excluded. </span><span style="color:black">Patients were divided into three cohorts according to baseline electrocardiographic and angiographic criteria: Cohort 1 (STEMI), Cohort 2 (non-ST segment elevation myocardial infarction (NSTEMI) without acute culprit occlusion) and Cohort 3 (NSTEMI with acute culprit occlusion). The primary endpoint was all­ cause mortality at one­ year after the index event.</span></span></span></span></span></p> <p style="text-align:justify"><span style="font-size:medium"><span style="background-color:white"><span style="font-family:"Times New Roman",serif"><span style="color:#000000"><strong><span style="color:black">Results: </span></strong><span style="color:black">A total of 555 patients were included and classified accordingly: Cohort 1 (n=317), Cohort 2 (n=200), and Cohort 3 (n=38). Mean age was 67.7 ± 13.4 years and 67.4% were male. At one-year, all-cause mortality occurred in 15.8% of patients in Cohort 1 versus 18.4% of patients in Cohort 3 (hazard ratio: 0.76; 95% CI: 0.36 - 1.59; p = 0.462) versus 5.6% in Cohort 2 (hazard ratio: 0.24; 95% CI: 0.10 - 0.59; p = 0.002). A trend that remained significant after multivariate adjustment</span></span></span></span></span><span style="font-size:medium"><span style="background-color:white"><span style="font-family:"Times New Roman",serif"><span style="color:#000000"><span style="color:black"> (hazard ratio: 0.28; 95% CI: 0.11 - 0.71; p = 0.007).</span></span></span></span></span></p> <p style="text-align:justify"><span style="font-size:medium"><span style="background-color:white"><span style="font-family:"Times New Roman",serif"><span style="color:#000000"><strong><span style="color:black">Conclusions:</span></strong><span style="color:black"> Patients with NSTEMI who have an occluded culprit have higher one-year all­-cause mortality than those who do not. These findings support the need for timely and accurate identification of patients with acute coronary occlusion.</span></span></span></span></span></p>
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