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The Influence of Cardiovascular Risk Factors on Restenosis and Mortality Following Percutaneous Coronary Intervention for Left Main Disease
Session:
Sessão de Posters 42 - Revascularização de tronco comum
Speaker:
Luísa Gomes Rocha
Congress:
CPC 2024
Topic:
H. Interventional Cardiology and Cardiovascular Surgery
Theme:
25. Interventional Cardiology
Subtheme:
25.2 Coronary Intervention
Session Type:
Cartazes
FP Number:
---
Authors:
Luísa Gomes Rocha; Gonçalo Terleira Batista; Tomás M. Carlos; Susana Costa; Bernardo Lisboa Resende; Mafalda Griné; Lino Gonçalves
Abstract
<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><span style="color:black"><strong>Background</strong><strong>:</strong> The decision to perform percutaneous coronary intervention (PCI) for chronic left main disease (LMD) has been subject of much debate. Nonetheless, the follow-up of these patients holds equal importance due to their high risk of death and need for reintervention. <span style="background-color:white"><span style="color:#222222">Understanding the clinical characteristics associated</span></span> <span style="background-color:white"><span style="color:#222222">with these critical </span></span><span style="background-color:white"><span style="color:#222222">events </span></span><span style="background-color:white"><span style="color:#222222">is crucial as they could influence </span></span>our approach, namely, by warranting angiographic review.</span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><span style="color:black"><strong>Purpose</strong><strong>:</strong> This study aimed to evaluate the impact of various cardiovascular risk factors on restenosis and mortality in patients who underwent PCI for LMD.</span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><span style="color:black"><strong>Methods:</strong> We conducted a retrospective single-center observational study, analyzing patients who underwent LMD PCI between January 2020 and December 2022. Data was gathered from hospital registries, documenting the presence of hypertension, dyslipidemia, obesity, diabetes and smoking habits. Evidence of restenosis and one-year mortality were recorded. Fisher exact tests were performed to assess correlation between these clinical variables and the incidence of restenosis and death. Due to considerable differences in sample sizes, separate analyses between elective and acutely treated patients were not feasible. Statistical significance was set at p<0.05.</span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><span style="color:black"><strong>Results:</strong> The study included a total of 72 patients (mean age 70.53 ± 11.64, 54 (75%) males). Among the participants, 50 (69.4%) had hypertension, 14 (19.4%) were smokers, 48 (66.7%) had dyslipidemia, 12 (16.7%) were obese, and 30 (41.7%) had diabetes. Elective PCI was performed in 11 patients (15.3%), while 60 (83.3%) needed acute intervention. Restenosis occurred in 6 patients (8.3%), and within the one-year follow-up period, 21 patients (29.2%) had died. Fisher exact tests revealed no significant association between cardiovascular risk factors and one-year mortality. However, diabetes significantly impacted restenosis (two tailed p=0.033). No other variable showed significant association.</span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><span style="color:black"><strong>Conclusions:</strong> Diabetes was the only cardiovascular factor that significantly impacted restenosis. This finding could potentially influence our future follow-up strategy for these patients. While no factor significantly impacted mortality, larger cohorts are essential for more conclusive and robust results.</span></span></span></p>
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