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FTO rs8050136 C>A variant is a risk factor for Metabolic Syndrome in a Portuguese Population
Session:
Sessão de Posters 24 - Biomarcadores em Cardiologia
Speaker:
Ana Débora Câmara de Sá
Congress:
CPC 2024
Topic:
J. Preventive Cardiology
Theme:
28. Risk Factors and Prevention
Subtheme:
28.14 Risk Factors and Prevention - Other
Session Type:
Cartazes
FP Number:
---
Authors:
Ana Débora Câmara De Sá; M.I. Mendonça; F. Sousa; G. Abreu; S. Freitas; E. Henriques; M. Rodrigues; S. Borges; A. Drumond; A.C. Sousa; R. Palma Dos Reis
Abstract
<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Metabolic Syndrome (MetS) involves complex genetic, environmental, lifestyle, and metabolic interactions. FTO rs8050136 encodes an RNA demethylase, which may affect many biological and metabolic processes. However, this genetic variant has never been investigated in portuguese populations.</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Aim:</strong> To investigate whether FTO gene variant<strong> </strong>rs8050136 C>A is a risk factor for Metabolic Syndrome in a portuguese population. </span></span></p> <p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Methods:</strong> <span style="color:#0d0d0d">We performed a case-control study with 3157 individuals. 1787 had MetS criteria, and 1370 did not. MetS was diagnosed according to the International Diabetes Federation (IDF) criteria.</span> FTO gene variant<strong> </strong>were genotyped by TaqMan real-time PCR. We evaluated bivariate analysis to calculate the relative risk of MetS (OR and 95% CI) and a multivariate logistic regression to display the independent variables associated with MetS.</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Results</strong>: CC genotypic percentages were 36.2% in the cases vs 36.7% in controls, CA was 46.6% vs 49.6%, and AA (risk) was 17.2% vs 13.7%. We investigated three genetic models, and the recessive AA vs (CC+CA) presented the best association with MetS (OR=1.31; 95%CI: 1.08-1.59, p=0.007). After multivariate logistic regression, this genetic model remained in the equation independently associated with MetS (OR=1.29; 95%CI: 1.06-1.58, p=0.013), together with physical inactivity (OR=1.72; p<0.0001), alcohol ingestion (OR=1.31; p=0.010) and age (OR=1.05; p<0.0001).</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Conclusion</strong>: In our population, genetic predisposition (FTO) played a role in susceptibility to MetS. However, it is just one piece of a much larger puzzle, with other factors, such as overall lifestyle, having the most significant impact on the risk of developing this condition.</span></span></p>
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