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18F-FDG uptake as a surrogate marker of vascular disease in breast cancer: the role of routine exams in cardiovascular risk evaluation
Session:
Sessão de Posters 12 - Cardio-oncologia e Medicina na Gravidez
Speaker:
Rafaela Fernandes
Congress:
CPC 2024
Topic:
K. Cardiovascular Disease In Special Populations
Theme:
30. Cardiovascular Disease in Special Populations
Subtheme:
30.6 Cardio-Oncology
Session Type:
Cartazes
FP Number:
---
Authors:
Rafaela Fernandes; João Borges-Rosa; Rodolfo Silva; Joana Moura Ferreira; Manuel Oliveira-Santos; Mariana Simões; Eric Monteiro; Gracinda Costa; Lino Gonçalves; Maria João Vidigal-Ferreira
Abstract
<p style="text-align:start"><span style="font-family:Calibri,sans-serif"><span style="color:#000000"><strong>Background</strong>: Inflammation is associated with cancer development and progression. The use of 18[F] Fluorodeoxyglucose (<sup>18</sup>F-FDG) PET-CT on diagnosis and monitoring of patients with breast cancer (BC) is based on its uptake by high metabolic state cells. We hypothesize that pro-inflammatory state in BC is associated with vascular inflammatory activity, independently of cardiovascular risk factors (CVRF).</span></span></p> <p style="text-align:start"><span style="font-family:Calibri,sans-serif"><span style="color:#000000"><strong>Methods</strong>: Single-centre retrospective observational study of consecutive women with BC under 55 years. Patients had to perform staging <sup>18</sup>F-FDG PET-CT before treatment and between 2018 and 2021. <sup>18</sup>F-FDG vascular uptake was obtained as tissue-to-background ratio (TBR) by measuring maximum standard uptake value (SUV) in the aorta and correcting it for blood pool activity. Tumour uptake was obtained as metabolic tumour volume (MTV). Total lesion glycolysis (TLG) was the product of MTV and tumour medium SUV. Data was collected through revision of informatized clinical files. Statistical analysis used T Student test or non-parametric equivalent tests for continuous variables, bivariate correlation and linear regression models. </span></span></p> <p style="text-align:start"><span style="color:#000000"><strong>Results</strong><span style="font-family:Calibri,sans-serif">: 45 women were included. Mean age was 43.3</span><span style="font-family:Symbol">±</span><span style="font-family:Calibri,sans-serif">7.59 years, most had no CVRF (35/81.4%). There was a positive correlation between total mean aortic TBR and MTV (</span><span style="font-family:Symbol">r</span><span style="font-family:Calibri,sans-serif">=0.318, </span><em>p-value</em><span style="font-family:Calibri,sans-serif">=0.040), and TLG (</span><span style="font-family:Symbol">r</span><span style="font-family:Calibri,sans-serif">=0.304, </span><em>p-value</em><span style="font-family:Calibri,sans-serif">=0.050). When analysing each aortic segment, a positive correlation was found between abdominal aortic TBR and MTV (</span><span style="font-family:Symbol">r</span><span style="font-family:Calibri,sans-serif">=0.507, </span><em>p-value</em><span style="font-family:Calibri,sans-serif">=0.001), and TLG (</span><span style="font-family:Symbol">r</span><span style="font-family:Calibri,sans-serif">=0.479, </span><em>p-value</em><span style="font-family:Calibri,sans-serif">=0.001). Linear regression stated that for every 1cm</span><sup>3</sup><span style="font-family:Calibri,sans-serif"> increase in MTV, abdominal aortic TBR increases by 0.001 (</span><em>p-value</em><span style="font-family:Calibri,sans-serif">=0.047), independently of baseline CVRF. </span></span></p> <p style="text-align:start"><span style="font-family:Calibri,sans-serif"><span style="color:#000000"><strong>Conclusion</strong>: Our study suggests that <sup>18</sup>F-FDG uptake in the abdominal aorta might be a promising surrogate marker of vascular inflammatory activity in patients with BC. Larger prospective studies with longer follow-up are necessary to evaluate if vascular inflammation results in CV events in cancer survivors.</span></span></p>
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