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Trends and Insights into Congenital Heart Disease Epidemiology in Portugal: A Two-Decade Perspective
Session:
Sessão de Posters 09 - Epidemiologia e formação médica
Speaker:
Joana Suarez
Congress:
CPC 2024
Topic:
J. Preventive Cardiology
Theme:
28. Risk Factors and Prevention
Subtheme:
28.14 Risk Factors and Prevention - Other
Session Type:
Cartazes
FP Number:
---
Authors:
Joana Suarez; Sérgio Laranjo; Conceição Trigo; Fátima F. Pinto
Abstract
<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="font-size:12.0pt"><span style="background-color:white"><span style="color:#222222">BACKGROUND AND AIM:</span></span></span></strong><span style="font-size:12.0pt"><span style="background-color:white"><span style="color:#222222"> We present data related to prenatal diagnosis (PND), demographic characteristics, prevalence, mortality and associated malformations of congenital heart disease (CHD) in Portugal from 2000 to 2019. </span></span></span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="font-size:12.0pt"><span style="background-color:white"><span style="color:#222222">METHOD:</span></span></span></strong><span style="font-size:12.0pt"><span style="background-color:white"><span style="color:#222222"> The cohort comprises 6,521 CHD cases from the Portuguese National Registry of Congenital Malformations.</span></span></span><br /> <br /> <span style="font-size:12.0pt"><span style="color:#222222"><strong><span style="background-color:white">RESULTS:</span></strong><span style="background-color:white"> The overall incidence of CHD increased from 326.6 per 100,000 live births in 2000 to 437.7 in 2019. The most common CHD type was left-to-right shunts, peaking at 314.62 per 100,000 in 2015. Critical CHDs showed a significant increase in PND, particularly for Tetralogy of Fallot and Hypoplastic Left Heart Syndrome, indicating advancements in diagnostic technology, improvement in prenatal diagnosis and increased awareness.</span><br /> <span style="background-color:white">The progressive improvement in medical care is shown through a decrease in non-survivors beyond the first week. Notably, there was also an increase in medical terminations of pregnancy after 2009, possibly due to enhanced detection of severe anomalies.</span><br /> <span style="background-color:white">In a sub-analysis of our cohort, 3,734 had other associated malformations, primarily from the Q80-Q89 group (other congenital malformations), followed by blood diseases (D50-D89 group). The average birth weight was approximately 2,731.6 grams. Prematurity and additional malformations significantly impacted survival, with non-survivors having a lower average birth weight (836.7 grams).</span><br /> <span style="background-color:white">Despite the increase in global incidence, we want to highlight that our cohort only reports malformations detected at birth and reported to the national registry. Being underestimated due to the lack of reporting of cardiac malformations detected later, this is the main limitation of this study.</span></span></span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="font-size:12.0pt"><span style="background-color:white"><span style="color:#222222">CONCLUSIONS:</span></span></span></strong><span style="font-size:12.0pt"><span style="background-color:white"><span style="color:#222222"> This comprehensive study provides insights into the evolving landscape of CHD in Portugal, emphasizing the importance of PND and the impact of associated malformations on patient outcomes.</span></span></span></span></span></p>
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