SPC365

Fibrinogen is associated to increased arterial stiffness on hypertensive individuals

Session: Sessão de Posters 19 - Genética em Cardiologia 1
Speaker: Ana Carolina Freitas Henriques

Congress: CPC 2024
Topic: F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
Theme: 20. Congenital Heart Disease and Pediatric Cardiology
Subtheme: 20.6 Congenital Heart Disease – Clinical
Session Type: Cartazes
FP Number: ---
Authors: Carolina Freitas Henriques; Ana Célia Sousa; Rui Fernandes; André Ferreira; Carolina Carvalhinha; Francisco Barreto; Mariana Rodrigues; Eva Henriques; Sofia Borges; Maria João Oliveira; Maria Isabel Mendonça; Roberto Palma Dos Reis

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;"><strong><span style="font-size:12.0pt">Introduction:</span></strong></span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;"><span style="font-size:12.0pt">Arterial </span><span style="font-size:12.0pt">elastic properties </span><span style="font-size:12.0pt">are important factors for the performance of cardiovascular function and predictors of cardiovascular risk. Increased blood pressure is a risk factor for cardiovascular disease. Arterial hypertension is the main risk factor for the development of arterial stiffness. Increased fibrinogen levels have been linked to target organ damage and cardiovascular outcomes. However, all these mechanisms at the arterial wall remain unknown.</span></span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;"><strong><span style="font-size:12.0pt">Objective:</span></strong></span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;"><span style="font-size:12.0pt">To evaluate whether fibrinogen levels are increased in a hypertensive population with high arterial stiffness.</span></span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;"><strong><span style="font-size:12.0pt">Methods:</span></strong> </span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;"><span style="font-size:12.0pt">In a sample of 860 hypertensive individuals, we determined the pulse wave velocity (PWV), using the Complior method, which is an index of arterial distensibility.</span> <span style="font-size:12.0pt">A case-control study was performed depending on whether they had high PWV (n=130) or not (n=730).</span> <span style="font-size:12.0pt">PWV was considered high when </span><span style="font-size:12.0pt">&ge;</span><span style="font-size:12.0pt">10 m/s.</span> <span style="font-size:12.0pt">Blood samples were collected from all individuals for biochemical analysis. The serum levels of fibrinogen were evaluated in both groups. A multivariate analysis was performed with other cardiovascular risk factors namely: diabetes, dyslipidemia, alcohol consumption and smoking to estimate which variables were significantly and independently associated with the arterial stiffness increase.</span></span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;"><strong><span style="font-size:12.0pt">Results:</span></strong> </span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;"><span style="font-size:12.0pt">Our results showed that, in a hypertensive population, individuals with higher PWV have increased serum fibrinogen levels than those with lower PWV (402.77 &plusmn; 93.10 versus 380.28 &plusmn; 80.75; p=0.004).</span> <span style="font-size:12.0pt">After logistic regression analysis, the risk factors that remained in the equation as significantly and independently associated with PWV increase were: </span><span style="font-size:12.0pt">diabetes (OR=2.138, CI 95% (1.400-3.264); p&lt;0.0001), alcohol (OR=1.511, CI 95% (1.027-2.224), p=0.036) and Fibrinogen (OR=1.003, CI 95% (1.001-1.005), p=0.006).</span> </span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;"><strong><span style="font-size:12.0pt">Conclusions:</span></strong> </span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;"><span style="font-size:12.0pt">We have confirmed with our results that fibrinogen is associated with a significant and independent increase in arterial stiffness in a hypertensive population. Changes in fibrinogen in both physiological and pathological conditions can increase blood viscosity and favor the onset of cardiovascular events.</span> <span style="font-size:12.0pt">Control measures must be implemented in hypertensive individuals to reduce arterial stiffness and consequently fibrinogen as a measure to prevent cardiovascular risk.</span></span></span></p>