SPC365

Is the triglyceride glucose index a valuable marker in the early identification of cardiovascular events?

Session: Sessão de Posters 10 - Dislipidémia e metabolismo lipídico
Speaker: Gonçalo Bettencourt Abreu

Congress: CPC 2024
Topic: J. Preventive Cardiology
Theme: 28. Risk Factors and Prevention
Subtheme: 28.14 Risk Factors and Prevention - Other
Session Type: Cartazes
FP Number: ---
Authors: Gonçalo Bettencourt Abreu; Maria Isabel Mendonça; Marco Serrão; Débora Sá; Francisco Sousa; Sónia Freitas; Mariana Rodrigues; Eva Henriques; Sofia Borges; António Drumond Freitas; Ana Célia Sousa; Roberto Palma Dos Reis

<h1 style="text-align:justify"><span style="font-size:16pt"><span style="background-color:white"><span style="font-family:&quot;Calibri Light&quot;,sans-serif"><span style="color:#2f5496"><strong><span style="font-size:11.0pt"><span style="font-family:&quot;Calibri&quot;,sans-serif"><span style="color:#212121">Introduction:&nbsp;</span></span></span></strong><span style="font-size:11.0pt"><span style="font-family:&quot;Calibri&quot;,sans-serif"><span style="color:#212121">Current research showed that the triglyceride glucose (TyG) index is a cheap clinical marker associated</span></span></span><span style="font-size:11.0pt"><span style="font-family:&quot;Calibri&quot;,sans-serif"><span style="color:#212121"> with calcium (CAC) score and atherosclerotic cardiovascular disease (CVD). </span></span></span><span style="font-size:11.0pt"><span style="font-family:&quot;Calibri&quot;,sans-serif"><span style="color:#212121">Nevertheless, its relationship with early atherosclerotic cardiovascular (ASCVD) events remains uncertain. </span></span></span></span></span></span></span></h1>

<h1 style="text-align:justify"><span style="font-size:16pt"><span style="background-color:white"><span style="font-family:&quot;Calibri Light&quot;,sans-serif"><span style="color:#2f5496"><strong><span style="font-size:11.0pt"><span style="font-family:&quot;Calibri&quot;,sans-serif"><span style="color:#212121">Objective</span></span></span></strong><span style="font-size:11.0pt"><span style="font-family:&quot;Calibri&quot;,sans-serif"><span style="color:#212121">: We intend to evaluate the association between the TyG index and CAC score, a marker of subclinical atherosclerosis, in a normal population free of apparent CVD. After that, we investigated whether this marker is a good tool to identify early CV events in an asymptomatic population.</span></span></span></span></span></span></span></h1>

<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="color:#212121">Methods:&nbsp;</span></strong><span style="color:#212121">We performed a prospective study with </span>1,284 subjects aged 51.8&plusmn;8.3, 73.5% male, without apparent coronary artery disease. CAC score was performed by cardiac computed tomography and reported as Agatston units. <span style="color:#131413">The TyG index was calculated as ln [TG (mg/dL) &times; FBG (mg/dL)/2], derived from previous studies and was subdivided into terciles.</span> <span style="color:#212121">Outcome variables were myocardial infarction, unstable angina, stroke, peripheric disease and CV death. The incidence of outcomes was estimated for each TyG tercile. All outcomes were investigated by Cox proportional hazards regression analysis adjusting for baseline covariates.</span></span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="background-color:white"><span style="font-family:Calibri,sans-serif"><strong><span style="color:#212121">Results</span></strong><strong><span style="color:black">:&nbsp;</span></strong><span style="color:black">Spearman&acute;s correlation, we obtain a positive correlation between TyG index and CAC (r=0.201; p&lt;0.0001). CV events were diagnosed in 47 participants during the follow-up period.</span></span></span></span></p>

<p style="text-align:justify"><span style="font-size:11pt"><span style="background-color:white"><span style="font-family:Calibri,sans-serif"><span style="color:black">In the low tercile (&lt;8.49), there were 20% of total ASCVD events, on the medium tercile [8.49-8.97[ there were 42.2%, and in the high (</span><span style="color:black">&ge;8.97) </span><span style="color:black">37.8% ASCVD events (p=0.145). &nbsp;Multivariate-adjusted hazard ratios (HRs) for subjects in the medium/highest TyG index tercile confirmed that these patients were at higher risk for CV events compared with participants in the lowest TyG index tercile after adjusting for smoking, hypertension, and dyslipidemia (HR = 2.552; 95% CI-1.144-5.693; p=0.022). </span></span></span></span></p>

<p><strong><span style="font-size:11.0pt"><span style="font-family:&quot;Calibri&quot;,sans-serif"><span style="color:#212121">Conclusions:&nbsp;</span></span></span></strong><span style="font-size:11.0pt"><span style="font-family:&quot;Calibri&quot;,sans-serif"><span style="color:#212121">Our study</span></span></span><span style="font-size:11.0pt"><span style="font-family:&quot;Calibri&quot;,sans-serif"><span style="color:#131413"> demonstrated that a higher TyG index is associated with a higher risk of ASCVD events using a representative cohort of a Portuguese population. </span></span></span><span style="font-size:11.0pt"><span style="font-family:&quot;Calibri&quot;,sans-serif"><span style="color:#212121">&nbsp;TyG index, which is inexpensive and easy to calculate, reflects insulin resistance and may be potentially helpful in identifying individuals at high risk of suffering early CV events. Then, it could be beneficial in primary CVD prevention.</span></span></span></p>