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Long-term outcomes of ventricular tachycardia ablation in patients with ischemic and non-ischemic cardiomyopathy: a propensity-score matched analysis
Session:
Sessão Melhores Comunicações Orais
Speaker:
Daniel A. Gomes
Congress:
CPC 2024
Topic:
P. Other
Theme:
37. Miscellanea
Subtheme:
08.4 Ventricular Arrhythmias and SCD - Treatment
Session Type:
Comunicações Orais
FP Number:
---
Authors:
Daniel A. Gomes; Mariana Sousa Paiva; Daniel Nascimento Matos; Ana Rita Bello; Gustavo Rodrigues; João Carmo; Francisco Moscoso Costa; Pedro Galvão Santos; Pedro Carmo; Diogo Cavaco; Francisco Bello Morgado; Pedro Adragão
Abstract
<p style="text-align:justify"><span style="font-family:Arial,Helvetica,sans-serif"><span style="font-size:12pt"><span style="color:black"><strong>Background:</strong></span></span></span></p> <p style="text-align:justify"><span style="font-family:Arial,Helvetica,sans-serif"><span style="font-size:12pt"><span style="color:black">Catheter ablation (CA) has been shown to be effective in the treatment of ventricular tachycardia (VT). Although some observational data suggest patients with non-ischemic cardiomyopathy (NCIM) have less favorable clinical outcomes when compared to those with an ischemic etiology (ICM), direct comparisons are scarcely reported. We aimed to compare the outcomes of VT ablation in a propensity score-matched population of ICM or NICM patients.</span></span></span></p> <p style="text-align:justify"> </p> <p style="text-align:justify"><span style="font-family:Arial,Helvetica,sans-serif"><span style="font-size:12pt"><span style="color:black"><strong>Methods:</strong></span></span></span></p> <p style="text-align:justify"><span style="font-family:Arial,Helvetica,sans-serif"><span style="font-size:12pt"><span style="color:black">Single-center observational registry including 246 consecutive patients with ischemic (ICM, N=166) and non-ischemic cardiomyopathy (NICM, N=80) who underwent drug-resistant VT ablation from 2012 to 2023. A propensity score (PS) was used to match patients in a 1:1 fashion according to the following variables: age, sex, left ventricular ejection fraction (LVEF), NYHA class, electrical storm (ES) at presentation, and previous endocardial VT ablation. The outcomes of interest were VT recurrence and all-cause mortality.</span></span></span></p> <p style="text-align:justify"> </p> <p style="text-align:justify"><span style="font-family:Arial,Helvetica,sans-serif"><span style="font-size:12pt"><span style="color:black"><strong>Results:</strong></span></span></span></p> <p style="text-align:justify"><span style="font-family:Arial,Helvetica,sans-serif"><span style="font-size:12pt"><span style="color:black">The PS yielded two groups of 71 patients each (mean age 63±10 years, 92.3% male, mean LVEF 35±10%, 35.9% with ES at presentation, and 23.2% with previous ablation), well matched for baseline characteristics. Those with NICM were more likely to undergo epicardial or combined VT ablation (43.7% vs. 9.9%, P<0.001). The procedural complication rate was low (4.9%, N=7) and similar between groups (P>0.05). </span></span></span></p> <p style="text-align:justify"><span style="font-family:Arial,Helvetica,sans-serif"><span style="font-size:12pt"><span style="color:black">During a median follow-up of 27 (IQR 15–45) months, patients with NICM had a significantly higher rate of VT recurrence (46.5% vs. 31.0%, log-rank P=0.037), although there were no differences regarding all-cause mortality (22.5% vs. 16.9%, log-rank P=0.245) – Figure. Multivariate analysis identified NICM (HR 2.34 [95% CI 1.32–4.14], P=0.004), NYHA class III/ IV (HR 2.11 [95% CI 1.11–4.04], P=0.024), and chronic kidney disease (HR 2.23 [95% CI 1.25–3.96], P=0.006), as independent predictors of VT recurrence. Non-inducibility of any VT immediately after ablation was associated with significantly lower rates of VT recurrence during follow-up (22.8%/ year vs. 42.4%/ year, log-rank P=0.03).</span></span></span></p> <p style="text-align:justify"> </p> <p style="text-align:justify"><span style="font-family:Arial,Helvetica,sans-serif"><span style="font-size:12pt"><span style="color:black"><strong>Conclusion:</strong></span></span></span></p> <p style="text-align:justify"><span style="font-family:Arial,Helvetica,sans-serif"><span style="font-size:12pt"><span style="color:black">NCIM patients are at increased risk of VT recurrence after ablation, although long-term mortality is similar to ICM in a propensity-matched cohort. Non-inducibility of any VT after CA is associated with better outcomes.</span></span></span></p>
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