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Stress in women: does it predict the type acute coronary syndrome?
Session:
Comunicações Orais - Sessão 05 - Doença cardiovascular na mulher
Speaker:
Margarida G. Figueiredo
Congress:
CPC 2023
Topic:
K. Cardiovascular Disease In Special Populations
Theme:
30. Cardiovascular Disease in Special Populations
Subtheme:
30.2 Cardiovascular Disease in Women
Session Type:
Comunicações Orais
FP Number:
---
Authors:
Margarida G. Figueiredo; Sofia B. Paula; Mariana Santos; Hélder Santos; Mariana Coelho; Samuel Almeida; Lurdes Almeida
Abstract
<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Introduction: In the last decades, there has been a significant increase in acute coronary syndrome (ACS) hospitalizations in young women, especially in those admitted for ST-elevation myocardial infarction (STEMI). Recent studies indicate that non-traditional risk factors, such as psychosocial stress may contribute substantially to the increasing risk noticed in this population, since depression and perceived stress (PS) are much more common in younger women. The 10-item Perceived Stress Scale (PSS-10) is a validated instrument to estimate stress levels in clinical practice. </span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Objective: To assess the impact of if PS in women ant if it was a predictor of non-ST-elevation myocardial infarction (NSTEMI).</span></span></p> <p style="text-align:justify"> </p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Methods: Single-center prospective study involving women hospitalized for ACS from 20/03/2019 to 31/03/2020. PSS-10 was completed during the hospitalization period. Patients were divided into two groups, according to the type of ACS: group A – STEMI; group B - NSTEMI. Follow-up of these patients was carried out until December 11, 2022, regarding death, readmissions (R) for cardiac causes and (R) for other causes. Logistic regression was performed to assess if PS was a predictor of NSTEMI.</span></span></p> <p style="text-align:justify"> </p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Results: PSS-10 score was higher in women than in men (22.90±6.90 vs 17.40±6.40, respectively). A total of 106 women with ACS were included, of whom 34 in group A and 57 in group B. Mean age was 58.41±10.03years in group A and 61.79±14.98years. There were no differences between the two groups regarding cardiovascular risk factors. Group A presented more with chest pain (86.9% vs 62.9%, p=0.002); there were no other statistically significant variables at presentation or regarding intrahospital complications between the two groups. In group A, PSS-10 score was 16.88 ± 6.584, and in group B 20.03 ± 5.18 (p=0.004). There were no differences in terms of death (5.90% in group A vs 17.50% in group B, p=0.199) or R for other causes (17.60% in group A vs 29.80% in group B, p=0.196). However, group B had more R for cardiac causes (36.10% vs 8.80% in group A, p=0.013). Logistic regression revealed that PS was a predictor of NSTEMI (odds ratio (OR) 1.001, p=0.006, confidence interval (CI) 1.003-1.018).</span></span></p> <p style="text-align:justify"> </p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Conclusions: This is the first prospective study carried out in the Portuguese population regarding this thematic, and showed that women had higher levels of PS, women with NSTEMI had more PS and that PS is a predictor of NSTEMI in women.</span></span></p> <p style="text-align:justify"> </p>
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