Login
Search
Search
0 Dates
2024
2023
2022
2021
2020
2019
2018
0 Events
CPC 2018
CPC 2019
Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
CPC 2020
CPC 2021
CPC 2022
CPC 2023
CPC 2024
0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
G. Aortic Disease, Peripheral Vascular Disease, Stroke
H. Interventional Cardiology and Cardiovascular Surgery
I. Hypertension
J. Preventive Cardiology
K. Cardiovascular Disease In Special Populations
L. Cardiovascular Pharmacology
M. Cardiovascular Nursing
N. E-Cardiology / Digital Health, Public Health, Health Economics, Research Methodology
O. Basic Science
P. Other
0 Themes
01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
37. Miscellanea
0 Resources
Abstract
Slides
Vídeo
Report
CLEAR FILTERS
A pilot characterization of patients with left ventricular arrhythmogenic and dilated cardiomyopathy
Session:
Posters (Sessão 4 - Écran 7) - Miocardiopatias hereditárias
Speaker:
Miguel Marques Antunes
Congress:
CPC 2023
Topic:
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
Theme:
17. Myocardial Disease
Subtheme:
17.7 Myocardial Disease - Other
Session Type:
Pósters Electrónicos
FP Number:
---
Authors:
Miguel Marques Antunes; André Ferreira; Diana Antunes; Isabel Cardoso; José Viegas; Pedro Brás; Sílvia Aguiar Rosa; Rui Cruz Ferreira
Abstract
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Background: While right ventricular (RV) arrhythmogenic cardiomyopathy (ACM) has been a recognized clinical syndrome for several years, left ventricle (LV) or bi-ventricular (BiV) ACM has only recently been identified as an independent clinical syndrome. Prior to the advent of genetic medicine, these patients (P) were mislabeled as having dilated cardiomyopathy (DCM). There is mounting evidence that patient outcomes and disease presentation differ among these entities, and hence a need to clinically and genetically characterize these distinct patient populations.</span></span></p> <p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Objectives: To evaluate multimodality imaging and clinical characterization differences between patients with genetically confirmed LV/BiV ACM and DCM.</span></span></p> <p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Methods: We conducted a retrospective analysis of all P with a clinical diagnosis of DCM and LV or Bi-V ACM followed in a cardiomyopathy clinic. These patients had to have a positive genetic test compatible with either disease phenotype and an identified pathologic or likely pathologic variant. All patients without a genetic test or with a variant of unknown significance were excluded. ACM was diagnosed according to the 2020 Padua Criteria. Patient characteristics, cardiac magnetic resonance (CMR) imaging, echocardiographic data, and cardiopulmonary exercise stress test data were extracted. Linear regression models Chi-squared and Wilcoxon signed rank tests were used to determine inter-group differences. </span></span></p> <p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Results: 27P were included, 17 with DCM and 10 with ACM diagnosis, 7 of which had isolated LV ACM. In the ACM group there were 5 LMNA, 2 PKP2, 1 DSP, 1 FLNC and 1 MYBPC3 P. In the MCD group there were 12 TTN, 3 MYBPC3 and 2 MYH7 P. Median age was 45 IQR (30-52), with 16 (58%) of patients being male and 22 (80%) caucasian. Patients with ACM had more baseline atrial fibrillation (50% vs 11%, p=0.029). They were more likely to be on class III antiarrhythmics (50% vs 12%, p=0.029), and less likely to receive beta-blocker therapy (70% vs 100%, p= 0.017). There were no statistical differences found in any of the echographic or CMR parameters, namely in LV and RV ejection fractions among both groups. Regarding CPET, inter-group differences did not differ with the exception of the presence of increased ventricular ectopy during exercise in the MCA group (40% vs 14%, p=0.042). General full P characteristics and pharmacotherapy are depicted in Table 1.</span></span></p> <p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Conclusion: In cohort of clinically and genetically confirmed DCM and LV/BiV ACM patients, individuals with LV/BiV ACM there were no major differences in morphological features, although arrhythmic events and pharmacological regiments varied between patients. We intend to further this multimodality imaging and exercise evaluation in the future in order to find better disease discriminators. </span></span></p>
Slides
Our mission: To reduce the burden of cardiovascular disease
Visit our site