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Behavioral and genetic risk factors associated with increased arterial stiffness
Session:
Posters (Sessão 3 - Écran 3) - Fatores de risco cardiovascular
Speaker:
Ana Célia Sousa
Congress:
CPC 2023
Topic:
J. Preventive Cardiology
Theme:
28. Risk Factors and Prevention
Subtheme:
28.14 Risk Factors and Prevention - Other
Session Type:
Pósters Electrónicos
FP Number:
---
Authors:
Ana Célia Sousa; Maria Isabel Mendonça; Mauro Fernandes; Duarte Ferreira; Rui Fernandes; Francisco Barreto; Eva Henriques; Sónia Freitas; Mariana Rodrigues; Sofia Borges; Maria João Oliveira; Graça Guerra; Ana Isabel Freitas; Ilídio Ornelas; Roberto Palma Dos Reis; Margarida Temtem
Abstract
<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,"sans-serif""><strong><span style="color:black">Background:</span></strong><span style="color:black"> Increased arterial stiffness occurs as a result of biological aging and atherosclerosis. Several behavioral and genetic factors, with complex interactions, are at the genesis of this increase. </span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,"sans-serif""><strong><span style="color:black">Objective:</span></strong><span style="color:black"> Study the behavioral and genetic factors associated with increased arterial stiffness.</span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,"sans-serif""><strong><span style="color:black">Methods:</span></strong><span style="color:black"> In 1712 individuals, the arterial stiffness was determined through Carotid-femoral Pulse Wave Velocity (CfPWV) by the Complior method. Two groups were considered, depending on the PWV values: 171 cases with PWV ≥10m/s (mean age 56.70±8.43; 60.8% male) and 1541 controls with PWV <10m/s (mean age 50.39±7.53; 49.9 % male). In both groups, the risk factors associated with increased arterial stiffness were studied, such as age, essential hypertension (EH), diabetes, dyslipidemia, smoking, alcohol habits and physical inactivity. A multiplicative genetic risk score (mGRS) was created with 14 genetic variants: AGT rs4762; AGT rs699; ACE rs4340; ACE rs4343; AGT1R rs5186; CYP11B2 rs1799998; CYP17A1 rs11191548; SCNN1G rs5718; </span><span style="color:#231f20">SLC4A2 rs2303934</span><span style="color:black">; ADD1 rs4961; ATP2B1 rs2681472; ADRβ1 rs1801253; ADRβ2 rs1042713 and GNβ3 rs5443. A logistic regression model estimated which variables were significantly and independently associated with increased arterial stiffness.</span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,"sans-serif""><strong><span style="color:black">Results:</span></strong><span style="color:black"> After the multivariate analysis, the variables that remained in the equation as significantly and independently associated with arterial stiffness increase were: EH (OR=3.273; p<0.0001), alcohol consumption (OR=1.635; p=0.005), diabetes (OR=1.556; p=0.038), age (OR=1.117; p<0.0001), and the multiplicative genetic score (OR=1.419; p<0.0001).</span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,"sans-serif""><strong><span style="color:black">Conclusion:</span></strong><span style="color:black"> In addition to behavioral risk factors, the genetic variants combined into a genetic risk score significantly contributed to the increase of arterial stiffness. Studying these mechanisms is important to better understand arterial stiffness pathophysiology to control vascular dysfunction.</span></span></span></p>
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