Login
Search
Search
0 Dates
2024
2023
2022
2021
2020
2019
2018
0 Events
CPC 2018
CPC 2019
Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
CPC 2020
CPC 2021
CPC 2022
CPC 2023
CPC 2024
0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
G. Aortic Disease, Peripheral Vascular Disease, Stroke
H. Interventional Cardiology and Cardiovascular Surgery
I. Hypertension
J. Preventive Cardiology
K. Cardiovascular Disease In Special Populations
L. Cardiovascular Pharmacology
M. Cardiovascular Nursing
N. E-Cardiology / Digital Health, Public Health, Health Economics, Research Methodology
O. Basic Science
P. Other
0 Themes
01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
37. Miscellanea
0 Resources
Abstract
Slides
Vídeo
Report
CLEAR FILTERS
Predictors of early mortality in infective endocarditis – a six-year single-centre retrospective study
Session:
Posters (Sessão 2 - Écran 8) - Endocardite
Speaker:
Margarida S. Cabral
Congress:
CPC 2023
Topic:
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
Theme:
16. Infective Endocarditis
Subtheme:
16.8 Infective Endocarditis - Other
Session Type:
Pósters Electrónicos
FP Number:
---
Authors:
Margarida S. Cabral; Sara Fernandes; Mariana Carvalho; Carolina Gonçalves; Rita Carvalho; Luís Graça Santos; Catarina Ruivo; João Morais
Abstract
<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Infective endocarditis (IE) has been described as a challenging infective disease, due to its presentation and clinical progression variability. Its mortality remains high besides better disease knowledge and therapeutic progress. This study aimed to describe the clinical, microbiological and echocardiographic characteristics and to identify the predictors of early mortality.</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">A retrospective study was conducted and patients diagnosed with definite or possible IE (according to the modified Duke criteria) between 2015 and 2021 were included. The main outcome was early mortality, including in-hospital and 3-month mortality. Group 1 represents patients alive 3 months after discharge and group 2 includes patients who died in the hospital or within 3 months after discharge. Group comparisons and multivariate logistic regression analysis were performed. A p-value less than 0.05 is statistically significant.</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Of the total 72 patients, 70.8% were male. The mean age was 68.7 years (Table 1). Fever was the main presentation feature at admission (Table 2). We counted 24 (33.3%) prosthetic valve endocarditis and 7 (9.7%) device-related IE. The most common isolated microorganisms were Streptococcus gallolyticus (n=11, 15.3%) and Enterococcus faecalis (n=10, 13.9%) (Table 3). Fourthy-eight patients (66.7%) developed local complications and 41 patients (56.9%) had systemic complications (Table 4). </span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">In-hospital mortality was 22.2% and early mortality was 29.2% (n=21). In univariate analysis, the predictors of early mortality were: diabetes (<em>p-value</em><0.01), fever at presentation (<em>p-value</em>=0.03) and sepsis during hospitalization (p-value<0.01). In multivariate analysis, only diabetes (OR=6.7, 95% CI [1.3, 34.9], <em>p-value</em>=0.02, AUC=0.856 [Fig.1]) was shown to be an independent factor of early mortality.</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Finally, twenty-two (30.6%) patients underwent surgical treatment, with a significant difference between groups with greater survival among those submitted to surgery (<em>p-value</em>=0.01). This subgroup population characterization and the main indications for surgical treatment are represented in Table 5. </span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">In conclusion, we identified diabetic patients as an independent high-risk subgroup of patients hospitalized for IE. These results suggest caution in the clinical management of these patients. In the future, it might plausibly be considered as a possible indicator for a more invasive and earlier strategy, regardless of the presence or absence of other clinical complications. Large-scale studies are needed to confirm these results.</span></span></p>
Slides
Our mission: To reduce the burden of cardiovascular disease
Visit our site