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Synergistic effect of two variants of the ACE gene on the appearance of obesity in a Portuguese population
Session:
Posters (Sessão 1 - Écran 8) - Dislipidémia, Diabetes e Obesidade
Speaker:
Ana Célia Sousa
Congress:
CPC 2023
Topic:
J. Preventive Cardiology
Theme:
28. Risk Factors and Prevention
Subtheme:
28.6 Obesity
Session Type:
Pósters Electrónicos
FP Number:
---
Authors:
Ana Célia Sousa; Roberto Palma Dos Reis; Jéssica Chaves; Fabiana Gouveia; Carolina Morna; Mauro Fernandes; Eva Henriques; Sónia Freitas; Mariana Rodrigues; Sofia Borges; Maria João Oliveira; Graça Guerra; Ana Isabel Freitas; Ilídio Ornelas; Maria Isabel Mendonça; Francisco Sousa
Abstract
<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,"sans-serif""><strong>Background:</strong> Obesity is an important risk factor for cardiovascular disease. Several studies prove that, in addition to behavioral factors, there is a strong genetic component underlying the wide variation in body weight. However, the identification of susceptibility genes has been very limited, as well as their respective interactions.</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,"sans-serif""><strong>Objective:</strong> The present work intends to investigate whether there is synergism between two genetic variants of Angiotensin Converting Enzyme (ACE), I/D and ACE A2350G, and the onset of obesity.</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,"sans-serif""><strong>Methods:</strong> A case-control study was performed with 873 male subjects: 246 obeses and 627 controls, without obesity. Obesity was considered when the body mass index was ≥30 kg/m<sup>2</sup>. The frequency of polymorphic variants of the ACE gene, ACE rs4340 I/D and ACE rs4343 A2350G, were evaluated in both groups and the Odds Ratio (OR) of having obesity was calculated under the inheritance models (dominant, recessive, additive and allelic). Finally, we evaluated the synergistic effect between the two variants of the ACE gene on the onset of obesity, through multivariate analysis.</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,"sans-serif""><strong>Results:</strong> There is a synergistic effect between the two ACE variants (DD and 2350GG) on the onset of obesity, in the recessive model (OR=1.528; 95%CI 1.107 – 2.110; p=0.010). When performing a multivariate analysis with other risk factors for obesity, namely age, diabetes and physical inactivity, the interaction between the two variants remained in the equation with statistical significance (OR = 1.513; 95% CI 1.098 - 2.087; p=0.011).</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,"sans-serif""><strong>Conclusions:</strong> There is a significantly and independently synergistic effect between the ACE genetic variants, rs4340 and rs4343, in the appearance of obesity in a male population. This result points to the existence of genetic variants of ACE that favor the appearance of obesity in our population. Obesity is not explained in a simple way with a single polymorphism in a gene, as there are synergistic effects between several polymorphisms of the same gene.</span></span></p>
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