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Polymorphisms of the Renin-Angiotensin-Aldosterone System are associated with obesity in a Portuguese population
Session:
Posters (Sessão 1 - Écran 8) - Dislipidémia, Diabetes e Obesidade
Speaker:
Ana Célia Sousa
Congress:
CPC 2023
Topic:
J. Preventive Cardiology
Theme:
28. Risk Factors and Prevention
Subtheme:
28.6 Obesity
Session Type:
Pósters Electrónicos
FP Number:
---
Authors:
Ana Célia Sousa; Roberto Palma Dos Reis; Carolina Morna; Jéssica Chaves; Diogo André; Fabiana Gouveia; Eva Henriques; Sónia Freitas; Mariana Rodrigues; Sofia Borges; Maria João Oliveira; Graça Guerra; Ana Isabel Freitas; Ilídio Ornelas; Maria Isabel Mendonça; Francisco Sousa
Abstract
<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,"sans-serif""><strong><span style="color:#202124">Background:</span></strong><span style="color:#202124"> Obesity is well recognized as a severe public health problem and results from complex interactions between multiple genes and environmental factors that remain poorly understood. Previous research points out that obesity activates the renin-angiotensin-aldosterone system (RAAS),</span> <span style="color:#231f20">increasing angiotensin </span>levels that are involved in energy balance and fat metabolism. However, these complex mechanisms need to be clarified. </span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,"sans-serif""><strong><span style="color:#202124">Objective:</span></strong><span style="color:#202124"> Investigate whether there is an association between two genetic RAAS variants</span> <span style="color:#202124">and the susceptibility to obesity in a Portuguese male population.</span></span></span></p> <p style="text-align:justify"><span style="font-size:12pt"><span style="font-family:"Times New Roman","serif""><strong><span style="font-size:11.0pt"><span style="font-family:"Calibri","sans-serif"">Methods:</span></span></strong><span style="font-size:11.0pt"><span style="font-family:"Calibri","sans-serif""> With a sample of 873 male participants selected from the control arm of GENHYMAPE study, two groups were formed: 246 with obesity and 627 non-obese. Obesity was considered when individuals presented a body mass index ≥30 kg/m<sup>2</sup>. ACE I/D rs4340 and ACE </span></span><span style="font-size:11.0pt"><span style="font-family:"Calibri","sans-serif"">2350 G>A rs4343 were genotyped in all individuals using Taqman Real-Time PCR assay (Applied Biosystems 7300 Real-Time). The chi-squared test was performed, and the probability (OR) of having obesity was calculated under the models of heredity, selecting the recessive as the best model. Subsequently, a multivariate logistic regression analysis was performed with ACE genetic variants, adjusted for the variables associated with obesity (age, diabetes and physical inactivity). </span></span></span></span></p> <p style="text-align:justify"><span style="font-size:12pt"><span style="font-family:"Times New Roman","serif""><strong><span style="font-size:11.0pt"><span style="font-family:"Calibri","sans-serif"">Results:</span></span></strong><span style="font-size:11.0pt"><span style="font-family:"Calibri","sans-serif""> The genetic variant ACE DD rs4340 was more frequent in the obese group (OR=1.408; p=0.024). Similarly, the second ACE variant, </span></span><span style="font-size:11.0pt"><span style="font-family:"Calibri","sans-serif"">2350 GG genotype, was more prevalent in the individuals with obesity (OR=1.507;p=0.010). After multivariate logistic regression, the ACE 2350 GG genotype remained in the equation (OR= 1.538; p=0.008), along with type 2 diabetes and physical inactivity (Table).</span></span></span></span></p> <p style="text-align:justify"><span style="font-size:12pt"><span style="font-family:"Times New Roman","serif""><strong><span style="font-size:11.0pt"><span style="font-family:"Calibri","sans-serif"">Conclusions:</span></span></strong><span style="font-size:11.0pt"><span style="font-family:"Calibri","sans-serif""> The genetic variants of RAS, ACE rs4340 and rs4343, are associated with the onset of obesity, but only the rs4343 showed an independent association with 54% increased probability of obesity. In the present work, polymorphic genetic alterations favour the onset of obesity and individuals carrying these genetic variants are more predisposed to developing obesity. Preventive measures, mainly lifestyle changes, should be implemented. </span></span></span></span></p>
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