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Cardiovascular outcomes according to risk category: results of a retrospective database study
Session:
Posters (Sessão 4 - Écran 5) - Risco Cardiovascular 2
Speaker:
Cristina Gavina
Congress:
CPC 2022
Topic:
J. Preventive Cardiology
Theme:
28. Risk Factors and Prevention
Subtheme:
28.2 Risk Factors and Prevention – Cardiovascular Risk Assessment
Session Type:
Pósters Electrónicos
FP Number:
---
Authors:
Cristina Gavina; Daniel Seabra; Marta Afonso-Silva; Diana Grangeia; Francisco Araújo; Tiago Taveira-Gomes
Abstract
<p><span style="font-size:11pt"><span style="font-family:Arial"><span style="color:#000000"><strong>Introduction</strong></span></span></span></p> <p><span style="font-size:11pt"><span style="font-family:Arial"><span style="color:#000000">This study aims to analyze the 10-year risk of death or hospitalization for atherosclerotic cardiovascular disease (ASCVD) by cardiovascular (CV) risk level.</span></span></span></p> <p><span style="font-size:11pt"><span style="font-family:Arial"><span style="color:#000000"><strong>Methods</strong></span></span></span></p> <p><span style="font-size:11pt"><span style="font-family:Arial"><span style="color:#000000">Retrospective population-based study using data from a Local Health Unit in Portugal. New patients in each CV risk category (defined according to the ESC/EAS 2019 guidelines) and ≥1 General Practice appointment in the three years prior to the date of inclusion (date of entry into the respective risk category) were analyzed. This analysis focused on the composite endpoint of 10-year risk of death (from any cause) or ASCVD hospitalization, by CV risk level. Death and hospitalization data were obtained from the corresponding ICD-9-CM and ICD-10-CM codes. Cox regression, sex- and age-adjusted, clustered per patient was used.</span></span></span></p> <p><span style="font-size:11pt"><span style="font-family:Arial"><span style="color:#000000"><strong>Results</strong></span></span></span></p> <p><span style="font-size:11pt"><span style="font-family:Arial"><span style="color:#000000">The total cohort consisted of 78,459 patients (low risk=32.6%, intermediate=28.8%, high=21.6%, very high=17.0%). Sociodemographic and clinical characteristics by CV risk, at the time of entry into the risk category, are depicted in Table 1. The 10-year risk of death or hospitalization for ASCVD was 1.7 times higher in intermediate-risk patients (HR=1.7; 95%CI:1.6-1.9), 2.7 times higher in high-risk (HR=2.7; 95%CI: 2.5-2.9) and 5.3 times higher in very high-risk (HR=5.3; 95%CI:4.9-5.7) compared to patients with low risk. </span></span></span></p> <p><span style="font-size:11pt"><span style="font-family:Arial"><span style="color:#000000"><strong>Conclusions</strong></span></span></span></p> <p><span style="font-size:11pt"><span style="font-family:Arial"><span style="color:#000000">These real-world evidence show an increased risk of death or ASCVD hospitalization in patients in higher CV risk categories, independently of sex and age, reinforcing the need of more effective disease management as patients’ CV risk increases. This corroborates the recommendations put forward by the ESC guidelines.</span></span></span></p>
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