SPC365

Pulmonary Embolism – platelet indices’ in patients with or without right ventricular dilatation

Session: Posters (Sessão 2 - Écran 3) - Ciência Básica
Speaker: Simão Pedro Almeida Carvalho

Congress: CPC 2022
Topic: O. Basic Science
Theme: 36. Basic Science
Subtheme: 36.5 Basic Science - Vascular Diseases
Session Type: Pósters Electrónicos
FP Number: ---
Authors: Simão de Almeida Carvalho; Lisa Ferraz; Pedro Carvalho; Diana Carvalho; Adriana Pacheco; Andreia Fernandes; Ana Briosa
<p style="text-align:justify"><span style="font-size:medium"><span style="font-family:Calibri,sans-serif"><span style="color:#000000"><strong>Introduction</strong>:</span></span></span></p>

<p style="text-align:justify"><span style="font-size:medium"><span style="font-family:Calibri,sans-serif"><span style="color:#000000">&nbsp; Platelets are essential components of the coagulation cascade, with physiopathologic impact on the development of innumerous thromboembolic diseases, such as pulmonary embolism (PE).</span></span></span></p>

<p style="text-align:justify"><span style="font-size:medium"><span style="font-family:Calibri,sans-serif"><span style="color:#000000">&nbsp;&nbsp;&nbsp;</span></span></span><span style="font-size:medium"><span style="font-family:Calibri,sans-serif"><span style="color:#000000">The platelet index - &lsquo;<em>Platelet Distribution Width&rsquo;</em>(PDW) &ndash; measures platelets&rsquo; size variation or anisocytosis. Studies have shown an association between an augmented PDW value and platelet activation, but despite of their routine measurement, their use as a gravity indicator for PE is reduced.</span></span></span></p>

<p style="text-align:justify">&nbsp;</p>

<p style="text-align:justify"><span style="font-size:medium"><span style="font-family:Calibri,sans-serif"><span style="color:#000000"><strong>Objective</strong>:</span></span></span></p>

<p style="text-align:justify"><span style="font-size:medium"><span style="font-family:Calibri,sans-serif"><span style="color:#000000">&nbsp; &nbsp;Measurement of quantifiable differences between platelet indices at diagnostic time in patients with or without right ventricle dilation. </span></span></span></p>

<p style="text-align:justify">&nbsp;</p>

<p style="text-align:justify"><span style="font-size:medium"><span style="font-family:Calibri,sans-serif"><span style="color:#000000"><strong>Methods:</strong></span></span></span></p>

<p style="text-align:justify"><span style="font-size:medium"><span style="font-family:Calibri,sans-serif"><span style="color:#000000">&nbsp; &nbsp;Single center cross-sectional study comprising 141 patients admitted to the emergency department due to PE with an echocardiographic evaluation at diagnosis time. Statistical analysis of data was performed using Independent-Samples T Test.</span></span></span></p>

<p style="text-align:justify">&nbsp;</p>

<p style="text-align:justify"><span style="font-size:medium"><span style="font-family:Calibri,sans-serif"><span style="color:#000000"><strong>Results:</strong></span></span></span></p>

<p style="text-align:justify"><span style="font-size:medium"><span style="font-family:Calibri,sans-serif"><span style="color:#000000">&nbsp; &nbsp;The total population (n=141) was subdivided in two groups &ndash; with - 51,1% - and without right ventricle dilation &ndash; 48,9%. <span style="color:black">There weren&acute;t significant differences between the two groups on gender (p=.108), history of previous PE (p=.542), Chronic Obstructive Pulmonary Disease (p=.091) and intra-hospital death (p=.056).</span></span></span></span></p>

<p style="text-align:justify"><span style="font-size:medium"><span style="font-family:Calibri,sans-serif"><span style="color:#000000">&nbsp; &nbsp;On comparison, the patients in the subgroup with right ventricle dilation were older (70,1 vs 63,9 years, <span style="color:black">p&lt;.05), had a higher percentage of positive I-troponin (86,8 vs 38,5%; p&lt;.05) and BNP at admission (81,6 vs 47,4%; p&lt;.05) and were submitted more frequently to fibrinolytic therapy </span>(22,5 vs 1,4%, p&lt;.05).</span></span></span></p>

<p style="text-align:justify"><span style="font-size:medium"><span style="font-family:Calibri,sans-serif"><span style="color:#000000">&nbsp; &nbsp;Patients with right ventricle dilation had a higher PDW value (16,2% vs 15.2%; p=.026) and lower total platelet count (200,7 vs 226,1 X 10E9/L; p=.043).</span></span></span></p>

<p style="text-align:justify">&nbsp;</p>

<p style="text-align:justify"><span style="font-size:medium"><span style="font-family:Calibri,sans-serif"><span style="color:#000000"><strong>Conclusion:</strong></span></span></span></p>

<p style="text-align:justify"><span style="font-size:12pt"><span style="color:#000000"><span style="font-family:Calibri,sans-serif">&nbsp; &nbsp;The study suggests that patients with right ventricle dilation have a higher PDW value and lower total platelet count when in comparison with patients without right ventricle dilation. These findings suggest a possible association between platelet indices and imagiologic gravity indicators on PE.</span></span></span></p>