Login
Search
Search
0 Dates
2024
2023
2022
2021
2020
2019
2018
0 Events
CPC 2018
CPC 2019
Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
CPC 2020
CPC 2021
CPC 2022
CPC 2023
CPC 2024
0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
G. Aortic Disease, Peripheral Vascular Disease, Stroke
H. Interventional Cardiology and Cardiovascular Surgery
I. Hypertension
J. Preventive Cardiology
K. Cardiovascular Disease In Special Populations
L. Cardiovascular Pharmacology
M. Cardiovascular Nursing
N. E-Cardiology / Digital Health, Public Health, Health Economics, Research Methodology
O. Basic Science
P. Other
0 Themes
01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
37. Miscellanea
0 Resources
Abstract
Slides
Vídeo
Report
CLEAR FILTERS
Synergism of two ACE gene variants in the onset of Hypertension in a Portuguese population
Session:
Comunicações Orais (Sessão 25) - Risco CV, Prevenção e Reabilitação Cardíaca 2 - Vários
Speaker:
Ana Célia Sousa
Congress:
CPC 2022
Topic:
J. Preventive Cardiology
Theme:
27. Hypertension
Subtheme:
27.5 Hypertension – Prevention
Session Type:
Comunicações Orais
FP Number:
---
Authors:
Ana Célia Sousa; Roberto Palma Dos Reis; Carolina Aguiar; Carolina Barros; Helena Luís; Mariana Gomes; Eva Henriques; Sónia Freitas; Mariana Rodrigues; Sofia Borges; Maria João Oliveira; Ana Isabel Freitas; Ilídio Ornelas; Maria Isabel Mendonça
Abstract
<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,"sans-serif""><span style="font-size:12.0pt">The Renin-Angiotensin-Aldosterone system is a important key in arterial hypertension (AHT) regulation. Genetic polymorphisms that interfere in this system are candidate genes for AHT genesis. Particularly, it has been described that genetic variants of angiotensin converting enzyme (ACE) are potentially associated with AHT in some populations, but not in others. The existence or not of synergistic actions between the ACE genetic variants in the appearance of AHT remains unknown.</span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,"sans-serif""><strong><span style="font-size:12.0pt">Objective:</span></strong><span style="font-size:12.0pt"> Investigate the association between ACE gene polymorphisms, ACE I/D rs 4340 and ACE A2350G rs4343, and AHT. Additionally, we aim to evaluate whether there is a synergism effect of ACE variants with AHT. </span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,"sans-serif""><strong><span style="font-size:12.0pt">Methods:</span></strong><span style="font-size:12.0pt"> A case-control study was performed with a total of 715 participants under the age of 50 years, including 339 hypertensive individuals and 376 controls. All collected blood for biochemical and genetic analysis. The frequency of polymorphic variants of the ACE gene, ACE I/D rs 4340 and ACE A2350G rs4343, were evaluated in both groups and the Odds Ratio (OR) was calculated under the inheritance models: dominant, recessive, additive and allelic. Finally, we evaluated the possible synergistic effect between the two ACE gene variants in the appearance of AHT through multivariate analysis.</span></span></span></p> <p style="text-align:justify"><span style="font-size:12pt"><span style="font-family:"Times New Roman","serif""><strong><span style="font-family:"Calibri","sans-serif"">Results:</span></strong><span style="font-family:"Calibri","sans-serif""> The genetic variant ACE DD was more frequent in the hypertensive individuals compared to controls (OR=1.472; CI 1.092–1.984; p=0.011). ACE 2350GG variant was also more prevalent for the AHT group with an OR of 1.524 (CI 1.029-2.258; p=0.035). </span></span></span></p> <p style="text-align:justify"><span style="font-size:12pt"><span style="font-family:"Times New Roman","serif""><span style="font-family:"Calibri","sans-serif"">A synergistic effect between the two variants in hypertension onset was verified with an AHT risk (OR) of 1.716 (CI 1.107-2.661; p=0.016).</span></span></span></p> <p style="text-align:justify"><span style="font-size:12pt"><span style="font-family:"Times New Roman","serif""><strong><span style="font-family:"Calibri","sans-serif"">Conclusion:</span></strong><span style="font-family:"Calibri","sans-serif""> This study showed the existence of a statistically significant association between ACE variants (DD and 2350GG) and AHT appearance. Additionally, a synergistic effect on AHT onset between the two variants studied was proved. This result highlights the existence of genetic variants of renin-angiotensin-aldosterone system that favor the appearance of AHT in our population. AHT is not explained in a simple way, with a single polymorphism of a gene, but with complex interactions of polymorfisms, as synergistic effects between polymorphisms of the same gene.</span></span></span></p>
Slides
Our mission: To reduce the burden of cardiovascular disease
Visit our site