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Meta-Analysis Comparing Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation With Versus Without Percutaneous Coronary Intervention
Session:
Comunicações Orais (Sessão 7) - Intervenção Cardíaca Coronária e Estrutural 1 - Válvula Aórtica
Speaker:
Gonçalo Ferraz Costa
Congress:
CPC 2022
Topic:
H. Interventional Cardiology and Cardiovascular Surgery
Theme:
25. Interventional Cardiology
Subtheme:
25.2 Coronary Intervention
Session Type:
Comunicações Orais
FP Number:
---
Authors:
Gonçalo Ferraz Costa; Vera Marinho; Diogo Fernandes; Joana Guimarães; Eric Monteiro; Marco Costa; Lino Gonçalves; Rogério Teixeira
Abstract
<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="font-size:10.0pt"><span style="font-family:"Bahnschrift SemiLight",sans-serif">Background</span></span></strong><span style="font-size:10.0pt"><span style="font-family:"Bahnschrift SemiLight",sans-serif">: Patients having transcatheter aortic valve implantation (TAVI) routinely undergo coronary angiography before the procedure to define the coronary anatomy and to evaluate the extend of coronary artery disease (CAD). Whether percutaneous coronary intervention (PCI) prior/concomitant with TAVI confers any additional clinical benefit in patients with CAD remains unclear.</span></span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="font-size:10.0pt"><span style="font-family:"Bahnschrift SemiLight",sans-serif">Purpose</span></span></strong><span style="font-size:10.0pt"><span style="font-family:"Bahnschrift SemiLight",sans-serif">: To compare the outcomes of PCI prior to TAVI in patients with significant coronary artery disease and severe aortic stenosis.</span></span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="font-size:10.0pt"><span style="font-family:"Bahnschrift SemiLight",sans-serif">Methods</span></span></strong><span style="font-size:10.0pt"><span style="font-family:"Bahnschrift SemiLight",sans-serif">: </span></span><span style="font-size:10.0pt"><span style="font-family:"Bahnschrift SemiLight",sans-serif">We systematically searched PubMed, Embase and Cochrane databases, in November 2021, for both retrospective and prospective studies comparing TAVI with PCI versus TAVI alone. Random-effects meta-analysis was performed.</span></span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="font-size:10.0pt"><span style="font-family:"Bahnschrift SemiLight",sans-serif">Results</span></span></strong><span style="font-size:10.0pt"><span style="font-family:"Bahnschrift SemiLight",sans-serif">: Eleven studies were included in which one was a randomized clinical trial. A total of 2530 patients were included, providing a 145 pooled death events (64 in TAVI with PCI and 81 in TAVI only). In terms of 30-day clinical outcomes, our pooled analysis revealed a similar all-cause mortality (pooled OR, 1.24; 95% CI [0.80, 1.93], P= 0.34; I²=27%), cardiovascular mortality (pooled OR, 1.44; 95% CI [0.56, 3.75], P= 0.45; I²=57%) and stroke (pooled OR, 1.07; 95% CI [0.53, 2.13], P= 0.86; I²=0%). However, our analysis revealed a higher rate of myocardial infarction (pooled OR, 4.28; 95% CI [1.56, 11.69], P<0.01; I²=0%) and major bleeding events (pooled OR, 1.40; 95% CI [1.02, 1.93], P=0.04; I²=0%) in the TAVI with PCI group. A 1-year clinical outcomes analysis revealed a trend for lower all-cause mortality in TAVI only group (pooled OR, 1.37; 95% CI [0.98, 1.91], P=0.06; I²=0%), similar cardiovascular death rate (pooled OR, 1.15; 95% CI [0.70, 1.89], P=0.59; I²=6%) and major bleeding events (pooled OR, 1.62; 95% CI [0.95, 2.76], P=0.07; I²=0%).</span></span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="font-size:10.0pt"><span style="font-family:"Bahnschrift SemiLight",sans-serif">Conclusion: </span></span></strong><span style="font-size:10.0pt"><span style="font-family:"Bahnschrift SemiLight",sans-serif">Our pooled data suggests that PCI with TAVI in patients with severe aortic stenosis and concomitant CAD grants no additional clinical advantage.</span></span></span></span></p>
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