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Essential Hypertension and ATP2B1 gene are associated with early arterial stiffness
Session:
Posters - J. Preventive Cardiology
Speaker:
Ana Célia Sousa
Congress:
CPC 2021
Topic:
J. Preventive Cardiology
Theme:
28. Risk Factors and Prevention
Subtheme:
28.14 Risk Factors and Prevention - Other
Session Type:
Posters
FP Number:
---
Authors:
Ana Célia Sousa; Carolina Aguiar; Carolina Barros; Helena Luís; Mariana Gomes; Eva Henriques; Sónia Freitas; Mariana Rodrigues; Sofia Borges; Carolina Freitas; Ana Isabel Freitas; Graça Guerra; Ilídio Ornelas; Roberto Palma Dos Reis; Maria Isabel Mendonça
Abstract
<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="font-size:12.0pt">Introduction: </span></strong><span style="font-size:12.0pt">Arterial distensibility is associated with an increased risk of cardiovascular disease; particularly early vascular stiffness is a determinant of morbidity and cardiovascular death. The carotid-femoral pulse wave velocity (PWV) is used as an index of arterial distensibility. Essential Hypertension (EH) is the main risk factor for increased vascular stiffness and, consequently, PWV. Some studies have associated the ATP2B1 A/G rs2681472 polymorphism to higher vascular remodeling.</span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="font-size:12.0pt">Objective: </span></strong><span style="font-size:12.0pt">Evaluate if the Essential Hypertension and ATP2B1 A/G polymorphism are associated with increased PWV in a population of individuals under 50 years.</span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="font-size:12.0pt">Methods:</span></strong><span style="font-size:12.0pt"> In a sample of 715 people aged <50 years, PWV was determined by the Complior method. PWV values were divided ??into quartiles and compared between the first (<7.1 m/s) and the fourth quartiles (>8.6 m/s) in relation to the frequency of EH and of the ATP2B1 A/G polymorphism. Two logistic regressions were performed: the first, with the variable EH and the second, with the genetic polymorphism ATP2B1 A/G added to EH. Subsequently, through a ROC curve, we evaluated the predictive power of high PWV values for EH and calculated its AUC. Then, a new ROC curve was completed with EH + ATP2B1 A/G and calculated its AUC.</span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="font-size:12.0pt">Results:</span></strong><span style="font-size:12.0pt"> EH was significantly associated with higher PWV values (p <0.0001). The ATP2B1 A/G polymorphism was also associated with higher PWV values, in the additive and multiplicative models ??(OR = 1.63, 95% CI 1.04-2.56; p = 0.033 and OR = 1.64, 95% CI 1.05-2.56; p = 0.030, respectively). The predictive power of high PWV conferred by EH was (AUC) 0.68, and when ATP2B1 A/G was added to EH the predictive power (AUC) was 0.70.</span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="font-size:12.0pt">Conclusions:</span></strong><span style="font-size:12.0pt"> Our study shows that ATP2B1 polymorphism and EH are significantly associated with greater arterial stiffness in individuals less than 50 years. It has also been proven the increase of the predictive capacity of PWV when adding the genetic variant ATP2B1 A/G to EH. Hypertensive individuals carrying this polymorphism have a higher risk of developing early arterial stiffness. Primary prevention measures must be instituted in these individuals as soon as possible to avoid progression to arterial stiffness and worsening of vascular remodeling. </span></span></span></p>
Slides
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