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BNP percentage decrease during hospitalization and its prognosis in heart failure
Session:
Posters - D. Heart Failure
Speaker:
Joana Laranjeira Correia
Congress:
CPC 2021
Topic:
D. Heart Failure
Theme:
11. Acute Heart Failure
Subtheme:
11.2 Acute Heart Failure – Epidemiology, Prognosis, Outcome
Session Type:
Posters
FP Number:
---
Authors:
Joana Laranjeira Correia; Inês Pires; Luísa Gonçalves; Vanda Neto; João Miguel Santos; Gonçalo Ferreira; António Costa; José Costa Cabral
Abstract
<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Introduction:</strong> Heart failure (HF) is an increasing problem for global healthcare systems and the endpoint of a variety of cardiovascular diseases. HF is a frequent cause of hospitalization, especially in the elderly. It is likely that the increasing burden of this disease will continue to pose challenges for modern healthcare. Several studies demonstrate that natriuretic peptides, such as BNP, are independent predictors of mortality.</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Aim:</strong> To analyse the BNP values at admission and at discharge of patients hospitalized due to acute HF and to evaluate the relationship between BNP decrease during hospitalization and and two outcomes: mortality and rehospitalization during a follow-up of 24 months. </span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Methods:</strong> A retrospective study of all consecutive patients admitted in the cardiology service with the diagnosis of acute HF was conducted. BNP percentage decrease during hospitalization was compared between the patients who died and patients who survived during the following time intervals: hospitalization, on a 3, 6, 12 and 24-month follow-up. BNP percentage decrease during hospitalization was also compared between the patients who were re-hospitalized and patients who were not re-hospitalized during the following time intervals: on a 3, 6, 12 and 24-month follow-up. Statistical analysis was performed in SPSS and a p value <0.05 was considered statistically significant.</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Results: </strong>419 patients were included in the study; 53.7% were male and the mean age was 77.03±10.71 years. Intra-hospital mortality was 2.8%. The 24-month mortality and readmission rate were, respectively, 10.8% and 40%. </span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Comparing the BNP percentage decrease of the patients who survived and the patients who died, a, a statistically significant difference was found during hospitalization (34.30 ± 44.36 vs 7.64 ± 49.57, p = 0.041) and on a 3-month follow-up (37.55 ± 42.53 vs 13.60 ± 55.78, p = 0.015). No statistically significant difference was found at 6 months (37.74 ± 42.76 vs 21.43 ± 52.98, p = 0.059), at 12 months (39.23 ± 40.59 vs 26.06 ± 48.59, p = 0.063) and at 24 months (38.14 ± 40.99 vs 30.06 ± 47.44, p = 0.234).</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Comparing the BNP percentage decrease of the patients who were not re-hospitalized and the patients who were re-hospitalized no statistically significant difference was found at 3 months (38.10 ± 43.49 vs 28.33 ± 44.02, p = 0.093), at 6 months (37.79 ± 44.48 vs 32.90 ± 42.06, p = 0.351), at 12 months (39.28 ± 43.08 vs 35.22 ± 39.43, p = 0.384) or at 24 months (36.77 ± 44.70 vs 37.62 ± 38.87, p = 0.852).</span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong>Conclusion: </strong>In this population, the BNP percentage decrease during hospitalization was associated with a reduction in short-term mortality (in-hospital and 3-month mortality), a correlation that was not observed with long-term mortality and with the rate of re-hospitalization. Thus, BNP decrease can be a tool in the daily practice to identify patients who benefit from an earlier reevaluation and therapeutic optimization after discharge.</span></span></p>
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