Login
Search
Search
0 Dates
2024
2023
2022
2021
2020
2019
2018
0 Events
CPC 2018
CPC 2019
Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
CPC 2020
CPC 2021
CPC 2022
CPC 2023
CPC 2024
0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
G. Aortic Disease, Peripheral Vascular Disease, Stroke
H. Interventional Cardiology and Cardiovascular Surgery
I. Hypertension
J. Preventive Cardiology
K. Cardiovascular Disease In Special Populations
L. Cardiovascular Pharmacology
M. Cardiovascular Nursing
N. E-Cardiology / Digital Health, Public Health, Health Economics, Research Methodology
O. Basic Science
P. Other
0 Themes
01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
37. Miscellanea
0 Resources
Abstract
Slides
Vídeo
Report
CLEAR FILTERS
Interaction between genetic and non-genetic factors in the appearance of Kidney FailureMicroalbuminuria in hypertensive individuals
Session:
Posters - I. Hypertension
Speaker:
Ana Célia Sousa
Congress:
CPC 2021
Topic:
I. Hypertension
Theme:
27. Hypertension
Subtheme:
27.1 Hypertension – Pathophysiology and Mechanisms
Session Type:
Posters
FP Number:
---
Authors:
Ana Célia Sousa; Bela Machado; Mariana Bilreiro; Carolina Aguiar; Eva Henriques; Sónia Freitas; Mariana Rodrigues; Sofia Borges; Graça Guerra; Ana Isabel Freitas; Ilídio Ornelas; Roberto Palma Dos Reis; Maria Isabel Mendonça
Abstract
<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><span style="font-size:12.0pt"><span style="font-family:"Arial","sans-serif"">Essential hypertension (EH) is one of the main causes of kidney failure and the association between these two clinical conditions, considerably increases cardiovascular risk.</span></span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="font-size:12.0pt"><span style="font-family:"Arial","sans-serif"">Objective:</span></span></strong><span style="font-size:12.0pt"><span style="font-family:"Arial","sans-serif""> Evaluate the association and interaction between genetic and non-genetic factors in the onset of kidney failure/microalbuminuria in hypertensive individuals.</span></span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="font-size:12.0pt"><span style="font-family:"Arial","sans-serif"">Methods: </span></span></strong><span style="font-size:12.0pt"><span style="font-family:"Arial","sans-serif"">A total of 545 hypertensive individuals without diabetes (mean age 50.7 ± 7.9 years) entered in this study. All of them collected blood for biochemical analysis and 24-hours urine to determine microalbuminuria.<strong> </strong>A case-control study was performed depending on whether they had kidney failure/Microalbuminuria (n=75) or not (n=470). The factors associated with kidney failure were studied: age, gender, time of EH evolution, controlled hypertension and genetic variants associated with hypertension, namely </span></span><span style="font-family:"Arial","sans-serif"">ACE I/D rs4340, ACE A2350G rs4343, AGT T174M rs4762, </span><span style="font-family:"Arial","sans-serif"">AGT M235T rs699, AGTR1 A1166C rs5186, </span><span style="font-family:"Arial","sans-serif"">CYP11B2 -344 C/T rs1799998, ADD1 G460W rs4961,</span><span style="font-family:"Arial","sans-serif""> SCNN1G G-173A rs5718,</span><span style="font-family:"Arial","sans-serif""> ADRB1 R389G rs1801253, ADRB2 R16G rs1042713, CYP17A1 T/C rs11191548,</span><span style="font-family:"Arial","sans-serif""> GNB3 C825T rs5443, ATP2B1 A/G rs2681472</span><span style="font-size:12.0pt"><span style="font-family:"Arial","sans-serif"">. Logistic regression analysis was performed to estimate which variables were significantly and independently associated with the appearance of kidney failure /Microalbuminuria. Finally, we developed interaction models between genetic and non-genetic factors to assess the best model in the prediction of kidney failure /Microalbuminuria in hypertensives.</span></span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="font-size:12.0pt"><span style="font-family:"Arial","sans-serif"">Results:</span></span></strong><span style="font-size:12.0pt"><span style="font-family:"Arial","sans-serif""> Male gender (OR=1.967; CI 1.178-3.286; p=0.010) and the genetic variant ATP2B1 rs2681472 (OR=1.871; CI 1.204–2.908; p=0.005) were significantly and independently associated with kidney failure/Microalbuminuria in hypertensive patients. The best interaction model was the one that included time of EH evolution, male gender, age and ATP2B1, with cross-validation consistency of 9/10 and weighted test accuracy of 62%,</span></span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="font-size:12.0pt"><span style="font-family:"Arial","sans-serif"">Conclusion:</span></span></strong><span style="font-size:12.0pt"><span style="font-family:"Arial","sans-serif""> In our study we emphasize the importance of studying genetic variants and non-genetic factors in the appearance of kidney failure/Microalbuminuria in hypertensive patients, since their early detection can modify the course of its development.</span></span></span></span></p>
Slides
Our mission: To reduce the burden of cardiovascular disease
Visit our site