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CLEAR FILTERS
Left ventricle remodelling and mechanical improvement after Laparoscopic Sleeve Gastrectomy
Session:
CO 25- Covid19 e outros
Speaker:
Lígia Lopes Mendes
Congress:
CPC 2021
Topic:
P. Other
Theme:
37. Miscellanea
Subtheme:
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Session Type:
Comunicações Orais
FP Number:
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Authors:
Lígia Mendes; Isabel; Vasco Atalaia; Raquel Seiça; Hans Eickhoff
Abstract
<p style="text-align:justify"><span style="font-size:medium"><span style="font-family:Cambria"><span style="color:#000000"><strong>Background:</strong>Although obesity is a well-recognized risk factor for heart failure with preserved ejection fraction and weight loss improves prognosis underlying mechanisms are not yet completed understood.</span></span></span></p> <p style="text-align:justify"> </p> <p style="text-align:justify"><span style="font-size:medium"><span style="font-family:Cambria"><span style="color:#000000"><strong>Aims:</strong> <span style="font-size:13pt"><span style="font-family:Times"><span style="color:#1a1718">We studied the modification of mechanical deformation and workload of the left ventricle after weight loss in the wake of laparoscopic sleeve gastrectomy (LSG).</span></span></span></span></span></span></p> <p style="text-align:justify"><span style="font-size:medium"><span style="font-family:Cambria"><span style="color:#000000"><strong>Methods:</strong><span style="font-size:13pt"><span style="font-family:Times"><span style="color:#1a1718">Fourteen female patients undergoing LSG for standard indications were enrolled. All subjects underwent a physical examination with biometric evaluation, a glucose tolerance test, homeostatic model assessment of insulin resistance (HOMA-IR), and a comprehensive echocardiography performed according to the EACVI recommendations before surgery (0M) and 6 months post-operatively (6M). </span></span></span><span style="font-size:13pt"><span style="font-family:Times">All values are presented as mean with standard deviation. Pre-and postoperative time points were compared using a paired t-test. </span></span></span></span></span></p> <p style="text-align:justify"><span style="font-size:medium"><span style="font-family:Cambria"><span style="color:#000000"><strong>Results:</strong>Mean weight loss was 29 ±5.6 Kg (p< 0.0001), systolic blood pressure decreased by 24 ±16 mmHg (p<0,0001), and mean heart rate by 9 ±5 bpm (p<0,0001). HOMA-IR decreased from 5,2 ±2,6 to 1,8±1,6 (p=0,0001). Echocardiographic variables are shown in table 1.</span></span></span></p> <p style="text-align:justify"><span style="font-size:medium"><span style="font-family:Cambria"><span style="color:#000000"><strong>Conclusions:</strong>LSG induced significant weight loss at 6 months, decreased insulin resistance and improved left ventricle myocardial work efficiency. This last finding, the increase in GWE, was primarily driven by the increment in the longitudinal deformation, since there was a decrease in the afterload.</span></span></span></p>
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