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Causes of death in adult congenital heart disease
Session:
CO 18 - Cardiopatias Congénitas
Speaker:
José Miguel Ramos Viegas
Congress:
CPC 2021
Topic:
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
Theme:
20. Congenital Heart Disease and Pediatric Cardiology
Subtheme:
20.2 Congenital Heart Disease – Epidemiology, Prognosis, Outcome
Session Type:
Comunicações Orais
FP Number:
---
Authors:
José Miguel Viegas; Tânia Branco Mano; Bárbara Teixeira; Sofia Jacinto; Rita Teixeira; Tiago Rito; Ana Agapito; Fátima Pinto; Lídia de Sousa; Rui Cruz Ferreira
Abstract
<p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="color:#538135">Introduction: </span></strong></span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><span style="font-size:10.0pt">Mortality in adults with congenital heart disease (CHD) is known to be increased. Despite a significant raise in life expectancy over the last decades, it remains lower than for the general population. We aimed to analyse the circumstances of death and mortality patterns in adults with CHD (ACHD).</span></span></span></p> <p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="color:#538135">Methods: </span></strong></span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><span style="font-size:10.0pt">Retrospective analysis of adult patients (pts) with CHD followed in one terciary care center who died between 1980 and December 2020. Data relating to the cardiac diagnosis, comorbidities, interventions, complications and causes of death were evaluated.</span></span></span></p> <p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="color:#538135">Results: </span></strong></span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><span style="font-size:10.0pt">251 pts were included, 51% male, median age of death 41 (28). Most of the deceased patients had severe CHD (n=135), and 8% (n=21) had a congenital syndrome. Regarding causes of death, 166 pts (66%) died CHD-related, 24 pts (9%) died non-CHD related, and in 61 pts (24%) no information regarding the cause of death was available (Fig.1). The most common cause of CHD-related death was progressive heart failure (n=67, 40%), followed by sudden cardiac death (n=53, 32%). As expected, the age of death in pts with severe CHDs was lower than pts with mild or moderate CHD, yet no association was found between the complexity of the defect and the cause of death. Mortality patterns according to individual CHD are identified in Fig.2.</span></span></span></p> <p><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><strong><span style="color:#538135">Conclusion: </span></strong></span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><span style="font-size:10.0pt">The vast majority of ACHD pts die from CHD-related causes, with heart failure and sudden cardiac death being the leading causes of death. Variations in mortality patterns can be found according to individual CHD.</span></span></span></p>
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