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Three-dimensional myocardial deformation parameters are associated with functional capacity assessed by cardiopulmonary exercise testing in patients with hypertrophic cardiomyopathy
Session:
CO 21 - Miocardiopatias
Speaker:
Isabel Cardoso
Congress:
CPC 2021
Topic:
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
Theme:
17. Myocardial Disease
Subtheme:
17.3 Myocardial Disease – Diagnostic Methods
Session Type:
Comunicações Orais
FP Number:
---
Authors:
Isabel Gonçalves Machado Cardoso; Sílvia Aguiar Rosa; Luísa Branco; Ana Galrinho; Pedro Rio; Pedro Brás; Ana Sofia Silva; António Fiarresga; Luís Lopes; Miguel Mota Carmo; Rui Cruz Ferreira
Abstract
<p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><u>Introduction:</u> </span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><span style="background-color:white"><span style="color:black">Myocardial deformation parameters, derived from three-dimensional (3D) speckle-tracking echocardiography (3DSTE) are useful tools to determine left ventricular (LV) systolic function, and are often abnormal before a decline in ejection fraction (EF).</span></span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><u>Aims:</u> </span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">To study the correlation between systolic function evaluated by myocardial deformation parameters obtained by 3DSTE and functional capacity in patients with HCM. </span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><u>Methods:</u> </span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">HCM patients seen prospectively at outpatient cardiomyopathy clinic at a tertiary centre were included. <span style="background-color:white"><span style="color:black">Systolic function was assessed by strain measures – global longitudinal, circumferential and radial strain - obtain by 3DSTE, LVEF by 2D and 3D echocardiography were also assessed. Functional capacity was evaluated by CPET. </span></span></span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><u>Results:</u> </span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Of 67 P with HCM (mean age 57 ± 14 years, 41 males), 38 P (56.7%) were in New York Heart Association (NYHA) functional class I, 24 (35.8%) in class II and 5 (7.5%) in class III. 46P (68.7%) had obstructive (HCM), with a maximum LV wall thickness (MWT) of 20 (7) mm. 3DSTE and CPET parameters are reported in Table 1. </span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">3D global radial strain showed correlation with pVO2 (rs=0.336, p=0.006), as well as absolute values of longitudinal strain (rs=0.280, p= 0.024). No association was found between LVEF and pVO2. MWT did not correlate with 3DSTE strain measures. </span></span></p> <p style="text-align:justify"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><u>Conclusion:</u> </span></span><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif">Impaired myocardial deformation was associated with worse functional capacity assessed by peak oxygen consumption. </span></span></p>
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