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Polymorphisms of ACE gene are associated with the onset of Metabolic Syndrome in a Portuguese population
Session:
Painel 12- Prevenção / Reabilitação Cardíaca 2
Speaker:
Ana Célia Sousa
Congress:
CPC 2020
Topic:
J. Preventive Cardiology
Theme:
28. Risk Factors and Prevention
Subtheme:
28.7 Diabetes and the Heart
Session Type:
Posters
FP Number:
---
Authors:
Ana Célia Sousa; Sara Gouveia; Teresa Góis; António Silva; CATARINA NOBREGA; Andreia Pereira; Eva Henriques; Sónia Freitas; Mariana Rodrigues; Sofia Borges; Graça Guerra; Ilídio Ornelas@sesaram.pt; Roberto Palma dos Reis; Maria Isabel Mendonça
Abstract
<p>Metabolic syndrome (MS) is an increasingly prevalent condition in developed societies and carries an increased cardiovascular risk. Although it is known that several behavioral and genetic factors are in its genesis, genetic influence on the onset of this pathology remains unknown. The obesity and MS activate the renin-angiotensin-aldosterone system (RAAS), which is why it led us to study two important ACE variants, ACE I/D and ACE A2350G described as potentially linked to arterial hypertension or obesity.</p> <p><strong>Objective:</strong> Investigate whether there is an association between the polymorphisms ACE I/D and ACE A2350G and the MS onset.</p> <p><strong>Methods:</strong> Case-control study with 1711 individuals, 748 diagnosed with MS and 963 without MS. MS was defined according to the International Diabetes Federation (IDF) guidelines. Polymorphic variants of the ACE gene, ACE I/D and ACE A2350G were blindly evaluated in both groups and Odds Ratio (OR) under hereditary, dominant, recessive, additive and multiplicative models were calculated. Data was analyzed by SPSS and a p<0.05 was defined as significance threshold.</p> <p><strong>Results:</strong> ACE DD appeared more frequently in the group of individuals with MS compared to controls with an OR of 1.334 (p=0.004) in the recessive model, OR of 1.218 (p= 0.005) in the additive model and OR of 1.228 (p=0.004) in the multiplicative model. Likewise, ACE 2350 GG was more prevalent in the group with MS with an OR of 1.266 (p=0.024) in the recessive model, OR of 1.173 (p=0.024) in the additive model and OR of 1.169 (p=0.025) in the multiplicative model. </p> <p><strong>Conclusion:</strong> The genetic variants ACE DD and ACE 2350 GG were associated with the MS onset. This result points to the presence of polymorphic genetic alterations that favor the appearance of MS. Patients with these variants belonging to RAAS are more likely to develop MS, therefore they should control their behavioral factors in order to counteract the genetic tendency to develop MS, and its cardiovascular risk.</p>
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