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32. Cardiovascular Nursing
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Can we access cardiovascular risk in radiotherapy patients?
Session:
Painel 12 -Cardio-Oncologia / Farmacologia 1
Speaker:
André Azul Freitas
Congress:
CPC 2020
Topic:
K. Cardiovascular Disease In Special Populations
Theme:
30. Cardiovascular Disease in Special Populations
Subtheme:
30.6 Cardio-Oncology
Session Type:
Posters
FP Number:
---
Authors:
André Azul Freitas; Nuno Ferreira Campos; Carolina Carvalho; Rogerio Teixeira; Margarida Borrego; Elisabete Jorge; Lino Gonçalves
Abstract
<p><strong>Introduction:</strong> Radiotherapy (RT) may lead to several side effects including coronary, valvular and pericardial disease. However, pharmacological cardioprotection is not indicated yet. Calcium score by computed tomography (CT) has showed value predicting cardiovascular risk over traditional risk stratification. In this study we aimed to determine cardiovascular radiotherapy effects on calcium score by CT.</p> <p><strong>Methods:</strong> We conducted a retrospective observational study including all patients submitted to breast RT in 2017 at our hospital. A total of 235 patients were identified. A CT planning for RT was used as a basal assessment. After identifying patients with an adequate CT within a year after RT, 11 female patients were included in our analysis. Non-electrocardiography gated CT with a 3 mm slice thick reconstruction permitted the Agatston score calculation.</p> <p><strong>Results:</strong> Mean age was 67.2 ± 14 years. Median total calcium score was increased after RT (276 vs 696, p=0.005), particularly in pericardium (0 vs 71, p=0.018) and descending aorta (276 vs 553, p=0.08). Moreover, there was an increased calcium score in coronary arteries (8.45 vs 73.36, p=0.028) and cardiac valves (16.6 vs 66.6, p=0.03) but with no significant increases in aortic, mitral or tricuspid valve neither in coronary arteries when individually analysed. The total radiation dose was correlated with the increase in total calcium score (r²= 0.41, p=0.034). However, there were no differences regarding the irradiated breast (right vs left). Age was also not associated with calcium increase.</p> <p><strong>Conclusion:</strong> In this preliminary study on patients submitted to breast RT, an increase of calcium score in coronary, valvular, pericardial and aortic territories was found. Further studies are warranted regarding the ability of the calcium score to predict events in this at-risk population.</p>
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