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Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
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A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
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01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
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20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
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Blood Pressure and Arterial Stiffness in sickle cell disease (SCD) with (HT) and without hypertension (NHT)
Session:
Painel 7 - Hipertensão 1
Speaker:
Carlos Moreira
Congress:
CPC 2020
Topic:
I. Hypertension
Theme:
27. Hypertension
Subtheme:
27.6 Hypertension – Clinical
Session Type:
Posters
FP Number:
---
Authors:
Carlos Moreira; Nuno Vieira de Brito; Cristina Alcântara; Paula Alcântara; Fátima Veloso
Abstract
<p>Introduction: Pulse wave velocity (PWV) and aortic augmentation index (AI) are indicators of arterial stiffness and are increased in hypertension patients. Sickle cell disease (SCD) leads to chronic vasculopathy with multiple organ involvement, and probably the combination of the risk two factors increases the vascular lesion. The aim of this study is to evaluate the arterial stiffness and wave reflection in adult SCD.</p> <p>Methods: The study is a prospectively recruited adult that are send to the hypertension unit because high value of blood pressure determination. Patients underwent clinical examination, body mass index (BMI), routine laboratory tests (complete blood count, serum creatinine level), urine albumin/creatinine ratio measure), and a measure of carotid-femoral pulse wave velocity (cf-PWV) and augmentation index (AI) at a steady state. Patients were divided according the value off ambulatory blood pressure measure in HT and NHT. Both were also compared with a normal group (C ) with the same age and sex. The models were t-student and ANOVA oneway, with p <0.01 (two-tailed).</p> <p>Results: The study Included were 42 patients ( 24 HT/18 NHT) with SCD and 21 C match with the same age and sex. The BMI and routine parameters did not presented significant differences, also the values of cfPWV (C: 6.9+2.2; NHT: 8.4+2.7, HT 10.8+3.3, p<0,01) and the values of central AIx (C: 18.3+11.3; NHT: 23.6+9.7, HT 27.3+8.8, p<0,01) are significative different among the three groups, with an increase of both parameters in the groups with SCD, and this effect was potentiated by the hypertension.</p> <p>Conclusion: PWV and AI are deeply modified in SCD patients in comparison with healthy controls. The changes were detected in patients with SCD, but was more marked in those who have HT. These data suggest that SCD an important factor for cardiovascular disfunction, but when associated with hypertension the lesions are greater and these patients should be considered as high risk and treated accordingly.</p>
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