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Polymorphism of the epithelial sodium channel SCNN1G G(-173)A is associated with the hypertensive heart disease
Session:
Painel 7 - Hipertensão 1
Speaker:
Ana Célia Sousa
Congress:
CPC 2020
Topic:
I. Hypertension
Theme:
27. Hypertension
Subtheme:
27.2 Hypertension – Epidemiology, Prognosis, Outcome
Session Type:
Posters
FP Number:
---
Authors:
Ana Célia Sousa; Sara Gouveia; António Freitas Silva; CATARINA NOBREGA; Andreia Pereira; Mariana Rodrigues; Eva Henriques; Sónia Freitas; Graça Guerra; Ana Isabel Freitas; Sofia Borges; Maria Isabel Mendonça; Roberto Palma dos Reis
Abstract
<p><strong>Introduction: </strong>Hypertensive heart disease (HHD) is one of the cardiac complications of hypertension (AHT). It is associated with a higher risk of cardiovascular events. Several studies suggest the influence of genetic factors on the increase of left ventricular mass in hypertensive patients. Environmental factors such as excessive salt intake are also associated with HHD. Thus, polymorphisms that interfere in the water and sodium balance at the kidney level should be candidate genes in the development of this pathology, which is still poorly understood. SCNN1G G(-173)A rs5718 sodium epithelial channel polymorphism is associated with AHT, but it is unknown if it is associated with the development of HHD in hypertensive individuals.</p> <p><strong>Objective: </strong>To study whether there is an association between the polymorphism of the epithelial sodium channel (SCNN1G G(-173) A) and the appearance of hypertensive heart disease (HHD).</p> <p><strong>Methods: </strong>A case-control study was conducted with a total sample of 588 hypertensive individuals (mean age of 50.9±7.7), including 153 cases with HHD (mean age of 52.0±7.9) and 435 controls without HHD (mean age of 50.5±7.6). SCNN1G G(-173)A frequencies were evaluated in both groups and the genetic models for this variant were calculated. Predictive factors of HHD development (PF HHD) were assessed, namely: age, gender, time of AHT diagnosis and control of AHT. A logistic regression analyzed which PF HHD were associated with the appearance of HHD.</p> <p><strong>Results:</strong> SCNN1G polymorphism was associated with HHD onset under the recessive (OR=1.620; 95% CI: 1.066-2.462; p=0.023) and dominant (OR=1.508, 95% CI:1.005-2.261; p=0.046) models. After multivariate analysis, together with the PF HHD, this variant remained in the equation with an OR of 1.660 (95% CI: 1.083-2.546), p=0.020 (Table 1).</p> <p><strong>Conclusions:</strong> The polymorphism of the sodium epithelial channel SCNN1G G(-173)A is associated with HHD in hypertensive individuals. These results help us to uncover the genetic component in the development of HHD, which may be useful in clinical practice either to prevent HHD in hypertensive patients, or to establish more appropriate therapies for the regression of HHD.</p>
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