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Lipid Profile in Adult Healthy Population from Madeira Island
Session:
Painel 12 - Prevenção / Reabilitação Cardíaca3
Speaker:
Margarida Temtem
Congress:
CPC 2020
Topic:
J. Preventive Cardiology
Theme:
28. Risk Factors and Prevention
Subtheme:
28.4 Lipids
Session Type:
Posters
FP Number:
---
Authors:
Margarida Temtem; Marco Serrão; Andreia Pereira; Marina Santos; Flávio Mendonça; Joao Adriano Sousa; Joel Monteiro; Ana Célia Sousa; Sónia Freitas; Mariana Rodrigues; Ilídio Ornelas; A. Drumond de Freitas; Roberto Palma dos Reis; Maria Isabel Mendonça
Abstract
<p><strong>Background: </strong>Dyslipidaemia remains an important risk factor for Coronary Artery Disease (CAD), and consequently a cause of morbility and mortality worldwide.<br /> It is widely known that plasma level of LDL cholesterol (LDL-C) is strongly associated with atherosclerosis and CAD. According to the recent guidelines of dyslipidaemia the target values of LDL-C are increasingly demanding and it is recommended that, in a healthy population, LDL-C values should be below 115 mg/dL.</p> <p><br /> <strong>Purpose: </strong>To evaluate the lipid profile in adult healthy population from Madeira Island.<br /> </p> <p><strong>Material and Methods:</strong> The study consists of the evaluation and stratification of the lipid profile of 1433 asymptomatic individuals (median age 52.8±7.8 years and 76.5% men) free of known coronary heart disease, enrolled from GENEMACOR study controls. LDL-C was determined by chemical methods and mean values were calculated. According to the target values of dyslipidaemia guidelines, 4 groups were created: 1st with LDL-C <55 mg/dL; 2nd with LDL-C <70 mg/dL, 3rd LDL-C <115 mg/dL and remaining individuals with LDL-C≥115 mg/dL.<br /> </p> <p><strong>Results:</strong> In this population, the LDL-C mean value was 128,36mg/dL ±35.86 mg/dL. In the analysis of the different groups: 3.1% (n= 45) had LDL<55 mg/dL vs 96.9% (n=1388) that had LDL>55 mg/dL; 4.9% (n=70) had LDL <70 mg/dL vs 95.1% (n=1363) that had LDL>70 mg/dL and 38.5% (n= 551) had LDL <115 mg/dL vs 61.5% (n=882) that had LDL >115 mg/dL.</p> <p><strong>Conclusion:</strong> In our “healthy” population, whatever the cardiovascular (CV) risk, LDL-C value is above the guidelines recommendations in the majority (61.5%). This warns, first of all, for the emergence of behavioral measures and the need for a wide screening across general population. In people who remain at high risk, with high LDL-C levels, it is important to evaluate the need of pharmacological strategies in primary prevention of atherosclerosis and CAD.</p>
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