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High density lipoprotein cholesterol and alcohol consumption: are they related?
Session:
Painel 12 - Prevenção / Reabilitação Cardíaca3
Speaker:
M. Raquel Santos
Congress:
CPC 2020
Topic:
J. Preventive Cardiology
Theme:
28. Risk Factors and Prevention
Subtheme:
28.14 Risk Factors and Prevention - Other
Session Type:
Posters
FP Number:
---
Authors:
M. Raquel Santos; Andreia Pereira; Joao Adriano Sousa; Flávio Mendonça; Joel Monteiro; Margarida Temtem; Ana Célia Sousa; Mariana Rodrigues; Eva Henriques; Ilídio Ornelas; A. Drumond de Freitas; Maria Isabel Mendonça; Roberto Palma dos Reis
Abstract
<p><strong><u>Introduction:</u></strong> High density lipoprotein cholesterol (HDL-C) is known to be inversely related to coronary artery disease (CAD). Previous observational studies have consistently reported that individuals with moderate alcohol consumption have a lower risk of cardiovascular disease compared with that of nondrinkers and heavy drinkers. The beneficial effects of moderate drinking appear to be mediated in large part by alcohol-induced increases in HDL-C concentrations.</p> <p><strong><u>Objective:</u></strong> To evaluate if a moderate alcohol consumption (30-50g a day) is associated with higher levels of HDL-C in coronary patients.</p> <p><strong><u>Materials and methods: </u></strong>1676 patients selected from GENEMACOR study population, with at least one > 75% coronary stenosis by angiography (median age 53.3 ± 7.9 years, 78.6% male, median HDL 43.0 ± 11.1 mg/dL). Population was divided according to the HDL level quartiles (1<sup>st</sup> quartile HDL < 35.3 mg/dL; 2<sup>nd</sup> quartile HDL 35.3 – 42 mg/dL; 3<sup>rd</sup> quartile HDL 42 – 49 mg/dL; 4<sup>th</sup> quartile HDL > 49 mg/dL). Population of the 1<sup>st</sup> and 4<sup>th</sup> quartiles (825 patients, median age of 53.3 ± 8.0 years and 78.7% male) were adjudicated and prospectively followed-up by 5.0 ± 4.2 years. X<sup>2</sup> and T student tests were used to analyze the demographic, laboratorial, angiographic and anthropometric characteristics of the population.</p> <p><strong><u>Results: </u></strong>420 (50.9%) patients were included in the 1<sup>st</sup> quartile group (median age 53.2 ± 7.9 years, 85.7% men) and 405 (49.1%) patients were included in the 4<sup>th</sup> quartile group (median age 53.4±8.0 years, 71.4% men). The mean HDL level was higher in the population with moderate alcohol consumption (mean HDL 43.7±15mg/dL in patients with alcohol consumption <30g/day, mean HDL 48.8±16mg/dL in patients with moderate alcohol consumption and mean HDL 41.6±15mg/dL in patients with alcohol consumption >50g/day). From 104 (median age 51.9±7.9 years, 96.2% male) patients with a moderate alcohol consumption, 62.5% vs 37.5% were in 4<sup>th</sup> HDL quartile, p 0.01.</p> <p><strong><u>Conclusion: </u></strong>We conclude that in our population, a moderate alcohol consumption is associated with higher levels of HDL-C. However, even if there is a causal association between alcohol consumption and higher HDL cholesterol levels, it is suggested that efforts to reduce coronary heart disease risks concentrate on the control of another risk factors.</p>
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