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A. Basics
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01. History of Cardiology
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05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
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32. Cardiovascular Nursing
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Diabetes as a factor for increased NT-proBNP levels in patients without heart failure
Session:
Painel 12 - Prevenção / Reabilitação Cardíaca 1
Speaker:
Francisco Manuel Dias Cláudio
Congress:
CPC 2020
Topic:
J. Preventive Cardiology
Theme:
28. Risk Factors and Prevention
Subtheme:
28.7 Diabetes and the Heart
Session Type:
Posters
FP Number:
---
Authors:
Francisco Dias Cláudio; Rita Ribeirinho; Bárbara Batista; Ana C. Sousa; Tiago Tribolet de Abreu
Abstract
<p><strong>Background</strong></p> <p>Natriuretic peptides are of substantial medical value for the diagnostic evaluation of suspected heart failure (HF). However, there are several factors that influence their levels. Diabetes is a rather frequent comorbidity and is considered a risk factor for HF. Diabetes could be associated with NT-proBNP levels, in association with a subclinical dysfunction.</p> <p> </p> <p><strong>Objectives</strong></p> <p>Determine the impact of the presence of diabetes in the NT-proBNP levels in patients with and without clinical diagnosis of HF.</p> <p> </p> <p><strong>Methods</strong></p> <p>A 4-month prospective study, including all consecutive patients admitted to one of the medical wards of the Internal Medicine Department in our hospital. Patients were divided into two groups according to the existence of a clinical diagnosis of HF. For each patient, a characterization of demographic data, comorbidities, as well as determination of NT-proBNP, troponin I, haemoglobin and criteria for absolute and functional iron deficiency (ID) were collected. All patients with a diagnosis of heart failure had an echocardiogram performed. The influence of diabetes in the NT-proBNP levels was analysed for each group.</p> <p> </p> <p><strong>Results</strong></p> <p>The study included 284 patients of which 70 had a clinical diagnosis of HF. Patients with and without HF were similar in terms of sex (p=0.737) obstructive sleep apnoea (p=0.668), infection (p=0.406), acute kidney injury (AKI) (p=0.098), alcoholism (p=0.591), haemoglobin (p=0.098) and functional ID (p=0.164). Within the group of patients without HF, median NT pro-BNP was significantly higher in patients with diagnosis of diabetes (954pg/mL vs 479pg/mL, p <0.001). The same statistically significance was not found in patients with the diagnosis of HF (p=0.944).</p> <p> </p> <p><strong>Conclusion</strong></p> <p>Our study demonstrates a correlation between the presence of diabetes and higher levels of NT-proBNP, within the group of patients without HF diagnosis. The same was not significant within the HF group. Perhaps, a correlation between diabetes and asymptomatic HF could exist, and further studies with ventricular function (both diastolic and systolic) are warranted.</p>
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