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Influence of a Genetic Oxidative predisposition Score on HDL-cholesterol
Session:
Painel 8 -Doença Coronária 6
Speaker:
Andreia Pereira
Congress:
CPC 2020
Topic:
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
Theme:
12. Coronary Artery Disease (Chronic)
Subtheme:
12.2 Coronary Artery Disease – Epidemiology, Prognosis, Outcome
Session Type:
Posters
FP Number:
---
Authors:
Andreia Pereira; Marina Santos; Joao Adriano Sousa; Margarida Temtem; Flávio Mendonça; Ana Célia Sousa; Mariana Rodrigues; Eva Henriques; Ilídio Ornelas; Ana Isabel Freitas; A. Drumond de Freitas; Roberto Palma dos Reis; Maria Isabel Mendonça
Abstract
<p>Effect modification by oxidative status like smoking was observed in some candidate gene studies on lipids.We aimed to evaluate the interaction effect of an oxidative predisposition gene score (<em>O</em>-GRS) and HDL-C levels, in Coronary artery disease (CAD). </p> <p>METHODS:</p> <p>In 1627 patients selected from GENEMACOR population (53.2±7.7, 75.5%) Oxidative related SNPs were determined in 6 candidate genes associated with oxidative stress (MTHFD1L, MTHFR677, MTHFR1298, PON108, PON55 e PON192). Weighted genotypic predisposition SNP oxidative score was calculated according to the number of risk aleles (0,1-3,4-5,>5). Bivariate analysis was done to determine HDL predictors. Coefficients of O-GRS-scores and HDL quartiles were included in age- and sex-adjusted logistic regression model for CAD disease. Further adjustment for potential confounding variables that influence oxidative status (Diabetes, Smoking, Obesity) were used to fully adjust the model.</p> <p>RESULTS:</p> <p>Mean O-GRS was 4.3±1.5. Just 7 individuals (0.4%) had no risk alele for Oxidative stress, 484 (29.7%) had 1-3 risk aleles, 784 (48.2%) had 4 o 5 risk aleles, and 352 (21.6%) had 5 or more risk aleles. HDL-Cholesterol for first quartile was ≤38 mg/dl and >53mg/dl for the 4<sup>th</sup> quartile. Multivariate regression analysis just HDL variable was independently associated with CAD disease (OR=4.9; 4.0-6.1, p<0.0001). Fully adjusted model additionally identified diabetes (OR=3.1; 2.4-4.2, p<0.0001) and Smoking (OR=2.5; 2.0-3.1, p<0.0001) as independent predictors for CAD. HDL remained as independent predictor for CAD in the fully adjusted model (OR 3.8; 3.0-4.7,p<0.0001).</p> <p>CONCLUSIONS:</p> <p>In our population, we observed a significant influence of HDL load in CAD occurrence. Despite a possible HDL protective role to be dependent on oxidative status, no influence of genetic predisposition score for oxidative status in CAD was observed. Further studies should be performed to understand possible protective HDL in Atherosclerosis.</p>
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