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Predictors of high and low serum HDL-cholesterol in a Portuguese Population
Session:
Painel 6- Doença Coronária 4
Speaker:
Andreia Pereira
Congress:
CPC 2020
Topic:
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
Theme:
12. Coronary Artery Disease (Chronic)
Subtheme:
12.6 Coronary Artery Disease - Clinical
Session Type:
Posters
FP Number:
---
Authors:
Andreia Pereira; Marina Santos; Flávio Mendonça; Margarida Temtem; Joel Monteiro; Adriano Sousa; Ana Célia Sousa; Mariana Rodrigues; Sónia Freitas; Graça Guerra; A. Drumond de Freitas; Maria Isabel Mendonça; Roberto Palma dos Reis
Abstract
<p>Low HDL-C is the most common lipoprotein abnormality among patients with Coronary artery disease. Genetically higher HDL- levels were not associated with a reduced risk of myocardial infarction in contrast to genetic scores associated with reduced LDL levels. Genetic studies for polygenic HDL trait using genome-wide association (GWAS) studies have yet not driven a conclusive causal relationship.<br /> Objectives:<br /> To characterize high and low HDL cholesterol population according to biochemical, Traditional risk factors for CAD and body mass Index (BMI).To evaluate possible association between genetic CAD variants and concentrations levels of HDL-cholesterol.<br /> Methods: In 1676 patients from GENEMACOR study population (53.3±7.9 years and 78.6% male) with proven coronary disease (at least one >75% epicardial coronary stenosis by angiography) with a maximum Follow up of 5.01±4.2 years (interquartile range 1.96-7.57) HDL levels were analyzed in quartiles. First to 4th quartile HDL level (n= 825, mean age of 53.3±8.0 years and 78.7% male) comparison of genetic profile including 33 variants associated with CAD in south European populations, genotyped using standard Taqman technique (Applied Biosystems) with specifics primers. Forward logistic regression analysis was done for significant variables after bivariate analysis.<br /> RESULTS: In our population mean HDL in the 1rst quartile was 30.5±3.8gr/dl vs 58.1± 8.5mg/dl in the 4th quartile. Lower vs higher HDL quartile patients were more diabetic (40.5% vs 24.4%; p<0.0001), and with Higher alcohol consumption (>50gr/day 17.6% vs 14.8%, p=0.01). Lower HDL-cholesterol quartile patients had higher BMI (29.03±4.1 vs 27.5 ± 4.2, p<0.0001), Higher HS-C reactive protein (1.27±2.75 vs 0.75±2.72, p=0.06. Lipid profile associated with low HDL quartile was lower Total Cholesterol (169.1±43 vs 203.9±45.9, p<0.0001; Lower LDL (99.4±34.6 vs 118±38.5, p<0.0001) and higher Triglycerides (208.2±147 vs 140.2±142.4, p<0.0001). Lower quartile of HDL levels was associated with 5 genetic variants (MIA3 AA (10% vs 6.2%, p=0.021); SMAD3 CC (4.3% vs 8.9%, p=0.027); ZNF259 GG (4.5% vs 2.0%, p=0.001); KIF 6 CC (11% vs 8.9%, p=0.043), MTHFR1298 C (7.1% vs 9.9%, p=0.061). Multivariate regression analysis determined that Diabetes and moderate alcohol and ZNF259 genetic variant were independent genetic predictors of HDL. 2 Cellular cycle genetic variants namely MIA3 and SMAD were protective for low HDL levels.<br /> Conclusion:<br /> In our population, Diabetic patients were more likely to have lower HDL levels. Traditional lipid risk profile was not found to influence HDL levels in our index population possibly due to statin intervention. New genome wide variants located to the cellular cycle were associated with lower HDL levels. Based on this new data, interesting new cellular study lines may arise to explore the complex role for HDL functionality in Atherosclerosis.<br /> </p>
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