Login
Search
Search
0 Dates
2024
2023
2022
2021
2020
2019
2018
0 Events
CPC 2018
CPC 2019
Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
CPC 2020
CPC 2021
CPC 2022
CPC 2023
CPC 2024
0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
G. Aortic Disease, Peripheral Vascular Disease, Stroke
H. Interventional Cardiology and Cardiovascular Surgery
I. Hypertension
J. Preventive Cardiology
K. Cardiovascular Disease In Special Populations
L. Cardiovascular Pharmacology
M. Cardiovascular Nursing
N. E-Cardiology / Digital Health, Public Health, Health Economics, Research Methodology
O. Basic Science
P. Other
0 Themes
01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
37. Miscellanea
0 Resources
Abstract
Slides
Vídeo
Report
CLEAR FILTERS
Who’s too old for epicardial fat volume quantification?
Session:
Painel 4 - Arritmologia 5
Speaker:
Catarina Brízido
Congress:
CPC 2020
Topic:
C. Arrhythmias and Device Therapy
Theme:
05. Atrial Fibrillation
Subtheme:
05.4 Atrial Fibrillation - Treatment
Session Type:
Posters
FP Number:
---
Authors:
Catarina Brízido; Daniel Nascimento Matos; António Miguel Ferreira; Joao Adriano Sousa; Pedro Freitas; Gustavo Da Rocha Rodrigues; João Carmo; Francisco Moscoso Costa; Pedro Lopes Do Carmo; Diogo Cavaco; Francisco Bello Morgado; Miguel Mendes; Pedro Adragão
Abstract
<p><strong>Introduction:</strong></p> <p>Epicardial adipose tissue has been implicated in the pathophysiology of atrial fibrillation (AF) and was recently shown to be an independent predictor of AF relapse rate and severity after pulmonary vein isolation (PVI). However, its impact in older patients hasn’t been analyzed. The aim of this study was to assess the relative importance of pericardial fat in an older population of patients undergoing pulmonary vein isolation (PVI).</p> <p><strong>Methods: </strong></p> <p>Single-center retrospective study of symptomatic drug-resistant AF patients undergoing PVI from November/2015 to June/2019. Baseline demographics, clinical and imaging data including cardiac CT and clinical outcomes were collected and analyzed. Population was dichotomized according to age above or below 70 years of age and groups were compared. Epicardial fat volume was quantified by contrast-enhanced cardiac CT using a semi-automated method. The study endpoint was symptomatic and/or documented AF recurrence after a 3-month blanking period.</p> <p><strong>Results:</strong></p> <p>We assessed 575 patients (354 males, mean age 61±11 years, 449 paroxysmal AF), 145 of which were 70 or older. Compared to the younger cohort, these patients had an higher prevalence of women, lower BMI (27 kg/m<sup>2</sup> [IQR 24-30] vs 28 kg/m<sup>2</sup> [IQR 25-30] kg/m<sup>2</sup>, p=0.012), higher CHA<sub>2</sub>DS<sub>2</sub>-VASc score (3 [IQR 2-4] vs 1 [IQR 1-2], p<0.001) and larger indexed left atrial volumes (LAVi; 61mL [IQR 52-84] vs 54mL [IQR 47-66], p<0.001).</p> <p>Median pericardial fat volume was 2.96cm<sup>3</sup>/m<sup>2</sup> [IQR 2.99-4.00] in the overall population and was higher in older patients (HR 2.21cm<sup>3</sup>/m<sup>2</sup> [IQR 1.44-3.17] vs HR 1.87 cm<sup>3</sup>/m<sup>2</sup> [IQR 1.24-2.90]; p=0.016).</p> <p>During follow-up, 232 patients relapsed (40%), with similar recurrence rates between younger and older patients (40% vs 42%, p=0.63) according to Kaplan-Meier survival curve analysis (HR 1.10, 95%CI 0.82-1.48; log-rank p=0.519). Epicardial fat volume remained an independent predictor of AF relapse in this subset of patient (HR 1.06 [95%CI 1.28-2.00]; p<0.001), as did the presence of non-paroxysmal AF (HR 2.78 [95%CI 1.48-5.21]; p=0.001).</p> <p><strong>Conclusion:</strong></p> <p>Patients over 70 years old with drug-refractory symptomatic AF presented with higher epicardial fat volume. Epicardial fat burden showed similar predictive power for AF relapse after PVI in this subset of patients, representing a useful tool for intervention decision across this age spectrum.</p>
Slides
Our mission: To reduce the burden of cardiovascular disease
Visit our site