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A. Basics
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C. Arrhythmias and Device Therapy
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01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
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21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
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28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
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Effect of atrial fibrillation on NT-proBNP levels in patients without heart failure
Session:
Painel 4 - Arritmologia 5
Speaker:
Francisco Manuel Dias Cláudio
Congress:
CPC 2020
Topic:
C. Arrhythmias and Device Therapy
Theme:
05. Atrial Fibrillation
Subtheme:
05.9 Atrial Fibrillation - Other
Session Type:
Posters
FP Number:
---
Authors:
Francisco Dias Cláudio; Rita Ribeirinho; Bárbara Batista; Ana C. Sousa; Tiago Tribolet de Abreu
Abstract
<p><strong>Background</strong></p> <p>Natriuretic peptides are of substantial medical value for the diagnostic evaluation of suspected heart failure (HF). However, there are several factors that influence their levels. Atrial Fibrillation (AF) is thought to be associated with higher levels of NT-proBNP, thereby influencing the diagnostic evaluation of suspected HF.</p> <p> </p> <p><strong>Objectives</strong></p> <p>To evaluate the impact and association of the presence of AF in the values of NT-proBNP, in patients with and without diagnosis of HF. To evaluate NT-proBNP as a predictor of AF.</p> <p> </p> <p><strong>Methods</strong></p> <p>A 4-month prospective study, including all consecutive patients admitted to one of the medical wards of the Internal Medicine Department in our hospital. Patients were divided into two groups according to the existence of a clinical diagnosis of HF. For each patient, a characterization of demographic data, comorbidities, as well as determination of NT-proBNP, troponin I, haemoglobin and criteria for absolute and functional iron deficiency (ID) were collected. All patients with a diagnosis of heart failure had an echocardiogram performed. The influence of atrial fibrillation on NT-proBNP levels was analysed, on patients with and without a clinical diagnosis of HF.</p> <p> </p> <p><strong>Results</strong></p> <p>The study included 284 patients of which 70 had a clinical diagnosis of HF. Patients with and without HF were similar in terms of sex (p=0.737) obstructive sleep apnoea (p=0.668), infection (p=0.406), acute kidney injury (p=0.098), alcoholism (p=0.591), haemoglobin (p=0.098) and functional ID (p=0.164).Within the group without HF, the presence of AF was associated with a 11197pg/mL average increase of NT-proBNP levels, adjusted for acute kidney injury, infection and haemoglobin (p=0.002). Such a statistical meaningful association was not found within the group of patients with HF (p=0.812), even when analysing the subgroups with ejection fraction <50% or ejection fraction ≥ 50% (p=0.114 and p=0.075, respectively). For patients without HF, the AUC of NT-proBNP levels to predict AF was 0.74 (p<0.001).</p> <p> </p> <p><strong>Conclusion</strong></p> <p>In our study, the presence of AF had an impact on NT-proBNP levels only in patients without HF. In patients with HF, the presence or absence of AF does not have a significant impact in NT-proBNP levels. Moreover, NTpro-BNP levels seem to be a significant preditor of AF.</p>
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