Login
Search
Search
0 Dates
2024
2023
2022
2021
2020
2019
2018
0 Events
CPC 2018
CPC 2019
Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
CPC 2020
CPC 2021
CPC 2022
CPC 2023
CPC 2024
0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
G. Aortic Disease, Peripheral Vascular Disease, Stroke
H. Interventional Cardiology and Cardiovascular Surgery
I. Hypertension
J. Preventive Cardiology
K. Cardiovascular Disease In Special Populations
L. Cardiovascular Pharmacology
M. Cardiovascular Nursing
N. E-Cardiology / Digital Health, Public Health, Health Economics, Research Methodology
O. Basic Science
P. Other
0 Themes
01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
37. Miscellanea
0 Resources
Abstract
Slides
Vídeo
Report
CLEAR FILTERS
Chemoreflex overexcitation, baroreflex impairment, sympathovagal imbalance and multiple organ dysfunction induced by Lipopolysaccharide-exposed rats
Session:
Sessão de Comunicações Orais - Ciência Básica
Speaker:
Ângela Raquel Amaro Leal
Congress:
CPC 2020
Topic:
O. Basic Science
Theme:
36. Basic Science
Subtheme:
36.6 Basic Science - Other
Session Type:
Comunicações Orais
FP Number:
---
Authors:
Ângela Raquel Amaro Leal; Liana shvachiy; Vera Geraldes; isabel rocha; Hélder Mota Filipe
Abstract
<p>Animal models are essential to clarify the pathophysiological mechanisms of Sepsis. One of the most used is the Toxaemia model that serves to study the basic biology of sepsis. Here, we evaluate the effect of lipopolysaccharide (LPS)-induced systemic inflammation on hemodynamic responses over time in anaesthetized and unanesthetized rats. Male rats were injected IP with either LPS (12 mg/kg; LPS12 group) or saline (SHAM group). At 6 and 24 h post-injection, an autonomic evaluation was performed in both awake animals, with continuous radio-telemetry recording of blood pressure (BP), and in anesthetized animals, with BP, electrocardiogram (ECG), heart rate (HR), tracheal pressure, respiratory frequency (RF) continuously monitored. Biochemical analysis was executed to quantify organ dysfunction. LPS significantly induced a rise in BP, HR and RF, indicative of tachycardia and tachypnea. Increases in BP were corroborated by the elevation of norepinephrine and epinephrine serum concentrations. The higher RF was concomitant with a higher chemoreflex sensitivity. The autonomic data reveals an overexcitation of the sympathetic tone resulting in a sympathovagal imbalance, concomitant with a decrease in the baroreflex sensitivity.Serum analysis yielded higher levels of biomarkers for renal and liver dysfunction as well as pancreatic and neuromuscular injury. Our data suggest that during the early stages of the systemic inflammatory response, LPStreatment leads to the cardiovascular system loses the ability to control appropriately the arterial pressure due to the baroreflex impairment as well as the sympathovagal imbalance. Thereby, the present findings indicate that LPS exposure results in profound hemodynamic and neuronal modifications.</p>
Slides
Video
Our mission: To reduce the burden of cardiovascular disease
Visit our site