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Changes on diastolic function after physical exercise in a doxorubicin model - Preliminary results from Tracking3C translational project
Session:
Sessão de Comunicações Orais - Ciência Básica
Speaker:
Vera Geraldes
Congress:
CPC 2020
Topic:
O. Basic Science
Theme:
36. Basic Science
Subtheme:
36.3 Basic Science - Cardiac Diseases
Session Type:
Comunicações Orais
FP Number:
---
Authors:
Vera Geraldes; Filipa Machado; Ângela Raquel Amaro Leal; Pedro Parreira; isabel rocha
Abstract
<p>Advances in breast cancer (BC) therapy have improved the survival and quality of life of BC patients, however these improvements are attenuated by the cardiac dysfunction that may occur in a subset of patients which might be due to an increase in sympathetic (SNS) tone promoted by chemotherapy, contributing to left ventricular ejection fraction decrease and leading to chemotherapy discontinuation. Physical exercise has been shown to decrease SNS activity and counteract the negative effects of cancer therapies on the cardiovascular system.</p> <p>At present, it is not possible to predict which patients will be affected and the methods currently used are insufficient and insensible.</p> <p>Using animal experiments is possible to deeply evaluate cardiac function together with a larger anatomo-histological and molecular assessment of the heart. Therefore, the first task of the TRACKING3C project aimed to develop and functionally characterize a doxorubicin (DOX) animal model together with the exercise efficacy to mitigate the adverse cardiovascular effects evoked by treatment. For that, adult healthy female wistar rats (n=16), aged >3 months, were intraperitoneally treated with doxorubicin (DOX; 3,5 mg/Kg) at weekly intervals for up to 4 weeks. Half of the animals were included in moderate exercise training in a treadmill (30 min/day at 15 m/min) during the treatments. Routine echocardiography measurements were recorded at baseline and 1 week after of treatment. Upon anesthesia, blood pressure (BP), heart (HR) and respiratory rates (RR) were measured.</p> <p>Results show that DOX evokes bradypnea which was restored to normal values by physical training. Cardiovascular parameters remained unchanged upon DOX but systolic and diastolic pressures and cardiac output increased after exercise. This might be due to an increase in stroke volume due to longer diastoles as showed by echocardiography despite total peripheral resistance was not evaluated.</p> <p>Nevertheless still preliminary and needing complementary autonomic and molecular studies, these findings suggest that lifestyle interventions, namely moderate exercise, can improve cardiovascular health in at-risk populations.</p>
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