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Plasma Lipidomic Profiling in Heart Failure with Preserved Ejection Fraction
Session:
Sessão de Comunicações Orais - Ciência Básica
Speaker:
Sílvia O. Diaz
Congress:
CPC 2020
Topic:
O. Basic Science
Theme:
36. Basic Science
Subtheme:
36.3 Basic Science - Cardiac Diseases
Session Type:
Comunicações Orais
FP Number:
---
Authors:
Sílvia O Diaz; José Miguel Alvarenga; Francisco Vasques-Nóvoa; Francisca Saraiva; António S Barros; José A. Belo; Otília V. Vieira; Adelino Leite-Moreira
Abstract
<p><strong>Introduction:</strong> Despite increasing prevalence and impact on healthcare costs, the pathophysiological mechanisms of heart failure with preserved ejection fraction (HFpEF) remain poorly understood. Circulating plasma metabolites have long been a prominent source for potential cardiovascular disease (CVD) signature markers and especially, lipids may represent important traits for CVD characterization. However, a detailed evaluation of plasma lipidome in HFpEF patients is still lacking and may provide important mechanistic clues with potential therapeutic impact.</p> <p><strong>Aim:</strong> To evaluate lipidomic profile in stable HFpEF patients and its associations with clinical data.</p> <p><strong>Methods:</strong> Single-center and prospective cohort study including stable HFpEF patients (n= 51) and comorbidity-matched controls (n=9). Fasted plasma lipidome was performed using top-down shotgun analysis and lipidome composition. Multivariate (PCA and PLS-DA) were applied for data exploration purposes and to provide a data-driven hypothesis-generating mechanism, regarding the major lipids traits associated with the HFpEF as well as concerning the impact of statin therapy. Predictive models, based on multivariable logistic regression, were used to highlights the role of lipids classes and provide a semi-quantitative profile regarding the association between lipid classes and HFpEF and statin therapy.</p> <p><strong>Results</strong>: Analysing the plasma lipidome profile adjusted for age and HDL, it was possible to identify a characteristic profile associated with HFpEF trait which is mostly characterized by a relative elevation of triacylglycerides (TAGs). On the other hand, statin therapy show clearly an influence regarding phosphocholine lipid family, particularly PC(16:0) (1,2-dipalmitoyl-sn-glycero-3-phosphocholine).</p> <p><strong>Conclusions: </strong>Lipidomic analysis identified a subset of lipids differentially present in HFpEF patients, when compared with comorbidity-matched controls. Moreover, statin therapy significantly alters lipidomic profile in HFpEF patients.</p>
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