Login
Search
Search
0 Dates
2024
2023
2022
2021
2020
2019
2018
0 Events
CPC 2018
CPC 2019
Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
CPC 2020
CPC 2021
CPC 2022
CPC 2023
CPC 2024
0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
G. Aortic Disease, Peripheral Vascular Disease, Stroke
H. Interventional Cardiology and Cardiovascular Surgery
I. Hypertension
J. Preventive Cardiology
K. Cardiovascular Disease In Special Populations
L. Cardiovascular Pharmacology
M. Cardiovascular Nursing
N. E-Cardiology / Digital Health, Public Health, Health Economics, Research Methodology
O. Basic Science
P. Other
0 Themes
01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
37. Miscellanea
0 Resources
Abstract
Slides
Vídeo
Report
CLEAR FILTERS
Prevalence and prognostic association of hyperuricemia in heart failure patients with reduced ejection fraction
Session:
Posters 3 - Écran 7 - Insuficiência Cardíaca
Speaker:
Inês Sofia Pereira Oliveira
Congress:
CPC 2019
Topic:
D. Heart Failure
Theme:
10. Chronic Heart Failure
Subtheme:
10.2 Chronic Heart Failure – Epidemiology, Prognosis, Outcome
Session Type:
Posters
FP Number:
---
Authors:
Inês Pereira Oliveira; Daniel Seabra De Carvalho; Ana Leal Neto; Aurora Andrade; João A. G. Azevedo; Paula Pinto
Abstract
<p><strong>Introduction: </strong>Substantial evidence advocates that uric acid (UA) is an independent marker for adverse prognosis in chronic HF of varying severity. Serum UA, produced in the terminal step of purine nucleotide metabolism by xanthine oxidase (XO), seems to be a predictor of mortality in HFrEF, independent of chronic kidney disease (CKD). Whether UA is simply a marker of dismal prognosis or an active contributor in disease pathogenesis is currently unknown.</p> <p><strong>Purpose: </strong>To appraise the association of UA levels with clinical features and prognosis in pts with HF and reduced ejection fraction (HFrEF) in a Heart Failure Clinic (HFC).</p> <p><strong>Methods: </strong>Unicentric, retrospective analysis of pts followed in a HFC since 3/2011. Included pts with reduced ejection fraction (EF) (<50%) and previous diagnosis for at least 6 months. The pts were divided into 2 groups: hyperuricemic (G1) and with normal UA levels (G2). Hyperuricemia was defined has serum UA ≥7.0mg/dL. Clinical, demographic, analytical, electrical, echocardiographic characteristics and major cardiac events – HF hospitalization (HFhosp) and mortality (from cardiovascular cause (CVm) and non-cardiovascular cause (nCVm)) were analysed.</p> <p><strong>Results: </strong>Included 318 pts, mean age 60.4 ± 13.3 years and a mean body mass index (mBMI) of 27.9kg/m<sup>2</sup>. 74% were male. 41.5% had ischemic etiology. G1 consisting of 153 pts (48%) with mean age of 61.3±13.3 years. There were no differences in age, mBMI and cardiopathy etiology between groups.There were no significant differences in cardiovascular risk factors prevalence, except for smoking (43 vs 32%, p=0.032). The hyperuricemic group correlated positively with the presence of atrial fibrillation (AF) (42 vs 28%, p=0.009) and CKD (41 vs 22%, p<0.001). G1 had more right ventricular dysfunction and lower left ventricular EF (LVEF) at admission (p<0.001). LVEF remained significantly lower in G1 during follow-up (FU) (p=0.045). Although there were no significant differences regarding mortality, G1 pts had more HFhosp (20 vs 12%, p=0.046).</p> <p><strong>Conclusion: </strong>Hyperuricemia was particularly prevalent in this cohort. There were no associations with standard cardiovascular risk factors although hyperuricemic pts had more AF and CKD. Furthermore, higher levels of ventricular dysfunction were observed in this subgroup, with greater presence of biventricular dysfunction and HFhosp. </p>
Slides
Our mission: To reduce the burden of cardiovascular disease
Visit our site