Login
Search
Search
0 Dates
2024
2023
2022
2021
2020
2019
2018
0 Events
CPC 2018
CPC 2019
Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
CPC 2020
CPC 2021
CPC 2022
CPC 2023
CPC 2024
0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
G. Aortic Disease, Peripheral Vascular Disease, Stroke
H. Interventional Cardiology and Cardiovascular Surgery
I. Hypertension
J. Preventive Cardiology
K. Cardiovascular Disease In Special Populations
L. Cardiovascular Pharmacology
M. Cardiovascular Nursing
N. E-Cardiology / Digital Health, Public Health, Health Economics, Research Methodology
O. Basic Science
P. Other
0 Themes
01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
37. Miscellanea
0 Resources
Abstract
Slides
Vídeo
Report
CLEAR FILTERS
Predictors of cardiotoxicity after chemotherapy with anthracyclines
Session:
Posters 3 - Écran 5 - Doença CV em populações especiais
Speaker:
Pedro von Hafe Leite
Congress:
CPC 2019
Topic:
K. Cardiovascular Disease In Special Populations
Theme:
30. Cardiovascular Disease in Special Populations
Subtheme:
30.6 Cardio-Oncology
Session Type:
Posters
FP Number:
---
Authors:
Pedro Von Hafe Leite; Bebiana Faria; Geraldo Dias; Ana Filipa Cardoso; Liliana Oliveira; Ana Sofia Rolo; Ilda Faustino; Alexandra Teixeira; Filipa Canário Almeida; Jorge Silva; António Lourenço
Abstract
<p><strong>Background</strong>: Anthracyclines (AC) has been established in the treatment of solid tumors and haemato-oncological malignancies. However, it is known to induce type 1 myocardial toxicity resulting in left ventricular dysfunction.</p> <p><strong>Purpose</strong>: To identify the predictors of cardiotoxicity during follow-up of a population under treatment with AC.</p> <p><strong>Methods</strong>: Unicentric, retrospective study include 20 patients with clinical or subclinical left ventricular dysfunction (LVD) - defined by decline in initial ejection fraction (EF) of at least 5% to <55% with signs and symptoms of heart failure or asymptomatic decrease in EF of at least 10% to <55%, or decrease in global longitudinal strain > 15%. And a control group of 56 patients who received anthracycline chemotherapy, without LVD. Cardiovascular risk factors and treatment regimens were analyzed.</p> <p><strong>Results</strong>: Mean age is 55.05 ± 9.4 years in the group with LVD and 53.73 ± 11.6 in the control group.</p> <p>There was an association between the occurrence of LVD and AC cumulative dose (409.65 ± 45.62 vs 372.51 ± 66.9 6mg/m2, p = 0.032), concomitant treatment with anti-HER2 monoclonal antibodies (78.9% vs 35.7%, Pearson’s Chi square = 10.65, p = 0.001) and with fluoropyrimidines (26.3% vs 0%, Pearson’s Chi square = 11.84, p = 0.001). Finally, tobacco consumption also showed a correlation with LVD (15.80% vs 1.85%, Pearson’s Chi square = 5.34, p = 0.003).</p> <p>Logistic regression identified as statistically significant predictors for the development of LVD concomitant treatment with anti-HER2 monoclonal antibodies (p = 0.038) and AC cumulative dose (p = 0.022).</p> <p><strong>Conclusion</strong>: Concomitant treatment with anti-HER2 monoclonal antibodies and AC cumulative dose were independent predictors of left ventricular dysfunction in patients with tumor treated with anthracyclines. Results reinforce the importance of tighter follow-up in patients with these risk factors.</p>
Slides
Our mission: To reduce the burden of cardiovascular disease
Visit our site