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Effect of LPA gene on CAD risk among diabetic patients
Session:
Posters 2 - Écran 5 - Prevenção
Speaker:
Sofia Borges
Congress:
CPC 2019
Topic:
J. Preventive Cardiology
Theme:
28. Risk Factors and Prevention
Subtheme:
28.2 Risk Factors and Prevention – Cardiovascular Risk Assessment
Session Type:
Posters
FP Number:
---
Authors:
Sofia Borges; Roberto Palma dos Reis; Andreia Pereira; Joao Adriano Sousa; Micaela Rodrigues Neto; Flávio Mendonça; Joel Monteiro; Eva Henriques; Ana Isabel; Ilídio Ornelas; Isabel Mendonça
Abstract
<p><strong>Introduction:</strong> Previous research reported that LPA gene is a strong and independent predictor of CAD in non-diabetic patients but not in patients with type 2 diabetes. These results suggest that LPA gene might contribute less to CAD risk in patients with T2DM than in general population.</p> <p><strong>Objective: </strong>Investigate, in our population, the association between LPA gene CT variant and CAD risk among diabetic patients.</p> <p><strong>Methods: </strong>3050 individuals (1619 coronary patients and 1431 controls) were genotyped for LPA rs3798220 TT/CT. Pearson’s chi-squared test was applied to evaluate the association between LPA variants and CAD, firstly, in the general population and, secondly, in the group of patients with T2DM (n=735). Multivariate logistic regression was performed with LPA CT variant and 6 traditional risk factors (TRF) (smoking, dyslipidemia, diabetes, hypertension, family history of CAD and physical inactivity) in both general and diabetic population.</p> <p><strong>Results: </strong>In total population, LPA CT variant was found to be strongly and significantly associated with CAD with an OR of 2.32 (95%CI: 1.56-3.45; p<0.0001). However, this association was less pronounced in the diabetic population with a CAD risk of 1.38 (95%CI: 0.56-3.43) without statistical significance (p=0.485). In the presence of 6 major TRF, multivariate analysis showed that LPA CT remained a strong and independent predictor of CAD risk (OR= 2.34; 95%CI: 1.52-3.62; p<0.0001). In diabetic population, LPA was no longer an independent predictor for CAD by multivariate analysis.</p> <p><strong>Conclusions: </strong>Our results show that the effect of LPA gene on CAD risk among diabetic patients might be different from that in the general population. Diabetes status is such a strong risk factor that may attenuate the genetic effects of LPA on CAD risk. This may indicate a complex role of Lp (a) and diabetes interaction in cardiometabolic diseases. </p>
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