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Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
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0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
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01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
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Can albumin predict outcomes in patients with chronic heart failure and reduced ejection fraction?
Session:
Posters 1 - Écran 9 - Insuficiência Cardíaca
Speaker:
Marta Sofia Ferreira Fonseca
Congress:
CPC 2019
Topic:
D. Heart Failure
Theme:
10. Chronic Heart Failure
Subtheme:
10.2 Chronic Heart Failure – Epidemiology, Prognosis, Outcome
Session Type:
Posters
FP Number:
---
Authors:
Marta Ferreira Fonseca; José Maria Farinha; Sara Gonçalves; Catarina Sá; Tatiana Duarte; Rita Marinheiro; Rita Rodrigues; Rui Caria
Abstract
<p><strong>Introduction:</strong> Heart Failure with reduced ejection fraction (HFrEF) is a major public health concern. HFrEF patients are frequently reassessed during the course of their illness, which instigated the search for biomarkers for serial evaluations. Hypoalbuminemia is common in the presence of certain chronic diseases, usually associated with a worse prognosis. Although low levels of albumin are commonly found in patients with HFrEF, the relationship between them isn’t totally defined.</p> <p><strong>Purpose:</strong> To determine the prognostic value of hypoalbuminemia in patients with HFrEF.</p> <p><strong>Methods:</strong> We retrospectively evaluated patients with HFrEF, followed in a heart failure centre. Patients whose value of albumin was not determined initially were excluded. The population was characterized according to their clinical, laboratorial and echocardiographic characteristics. Patients were divided in two groups, based on the presence of hypoalbuminemia (≤3,4g/dL). The adverse events considered were the occurrence of HF hospitalizations or death.</p> <p><strong>Results:</strong> We studied 167 patients (61% were males) with a mean age of 68±11 years and a median left ventricle ejection fraction (LVEF) of 31±8%. The mean value of albumin was 3,5±0,6g/dL and 41% of the patients presented with hypoalbuminemia. Body mass index (BMI) was lower (19 kg/m<sup>2</sup> vs. 24 kg/m<sup>2</sup>, p=0,01) and brain natriuretic peptides (BNP) values were higher in patients with lower values of albumin (255 (109-1020) pg/ml vs. 152 (42-356) pg/ml, p=0,01). Also, patients with hypoalbuminemia were less often treated with mineralocorticoid receptor antagonists (18% vs. 46%, p<0,001). In Multivariable Cox regression analysis, hypoalbuminemia was independently associated with HF hospitalizations and showed a tendency towards the occurrence of death (table 1 and 2).</p> <p><strong>Conclusion:</strong> In this group of patients, hypoalbuminemia was independently associated with HF hospitalizations and showed a tendency towards the occurrence of death. These findings suggest that albumin may predict outcomes in HFrEF patients with incremental value besides BMI and cachexia states.</p>
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