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Curso de Atualização em Medicina Cardiovascular 2019
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Non-genetic and genetic factors that predict target organ damage in hypertensive patients
Session:
Posters 1 - Écran 7 - Hipertensão Arterial
Speaker:
Ana Célia Sousa
Congress:
CPC 2019
Topic:
I. Hypertension
Theme:
27. Hypertension
Subtheme:
27.2 Hypertension – Epidemiology, Prognosis, Outcome
Session Type:
Posters
FP Number:
---
Authors:
Ana Célia Sousa; Roberto Palma dos Reis; Joel Monteiro; Paula Faria; Susana Gomes; Andreia Pereira; Mariana Rodrigues; Eva Henriques; Sónia Freitas; Ana Isabel; Graça Guerra; Ilídio Ornelas; A. Drumond de Freitas; Maria Isabel Mendonça
Abstract
<p><strong>Introduction:</strong> Essential Hypertension (EH) is a risk factor for cardiovascular disease. Target organ damage (TOD) influences the prognosis of a hypertensive population, since it is an independent determinant of overall cardiovascular risk.</p> <p>Predicting these complications is of high interest regarding that they are associated with a prognostic implication. In addition, the detection of TOD risk factors may help to define prevention and/or treatment strategies, either individually or as a group.</p> <p><strong>Objective:</strong> To evaluate the non-genetic and genetic factors that are associated with the advent of TOD in hypertensive individuals.</p> <p><strong>Methods:</strong> In a group of 600 hypertensive patients, the presence of TOD, namely, hypertensive retinopathy, renal insufficiency/microalbuminuria, hypertensive cardiopathy and cerebrovascular disease were evaluated. We separated and compared two groups according to whether or not they had at least one TOD. The group of cases (with TOD) had 308 individuals and 292 were considered controls. We evaluated the factors associated with the appearance of TOD in both groups: age, gender, time of evolution of EH and controlled hypertension, and the following genetic variants associated with EH: rs4340, rs4343, rs4762, rs699, rs5186, rs1799998, rs1801253, rs1042713, rs4961, rs5718, rs5443, rs2681472 and rs11191548.</p> <p>Logistic regression analysis was performed to estimate which variables were significantly and independently associated with the appearance of TOD. Data analysis was done using SPSS version 19.0.</p> <p><strong>Results:</strong> Variables associated with the appearance of TOD in hypertensive patients were the male gender with OR 1.44 (p=0.033), the time of evolution of EH with OR 1.03 (p=0.026) and the genetic variants <em>ADRB1</em> with OR 1.66 (p=0.003) and <em>ATP2B1</em> with OR 1.49 (p=0.036) (table 1).</p> <p><strong>Conclusions:</strong> We may conclude that the variables that were associated with the appearance of TOD in hypertensive patients were the male sex, the time of evolution of AH and the genetic variants <em>ADRB1</em> and <em>ATP2B1</em>. We highlight the importance of studying the influence of genetic variants and non-genetic factors in the appearance of TOD in hypertensive patients in order to institute therapies as early and sustainable as possible.</p>
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