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CPC 2019
Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
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0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
G. Aortic Disease, Peripheral Vascular Disease, Stroke
H. Interventional Cardiology and Cardiovascular Surgery
I. Hypertension
J. Preventive Cardiology
K. Cardiovascular Disease In Special Populations
L. Cardiovascular Pharmacology
M. Cardiovascular Nursing
N. E-Cardiology / Digital Health, Public Health, Health Economics, Research Methodology
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01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
37. Miscellanea
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The dilated phenotype in left ventricular non-compaction cardiomiopathy
Session:
Posters 1 - Écran 4 - Doenças do Miocárdio
Speaker:
Nuno Craveiro
Congress:
CPC 2019
Topic:
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
Theme:
17. Myocardial Disease
Subtheme:
17.2 Myocardial Disease – Epidemiology, Prognosis, Outcome
Session Type:
Posters
FP Number:
---
Authors:
Nuno Craveiro; Hugo Da Silva Antunes; Nuno Marques; Liliana Reis; Rui Santos; Ana Almeida; Olga Azevedo
Abstract
<p>Introduction: Patients with left ventricular non-compaction cardiomyopathy (LVNC) have a higher prevalence of heart failure, ventricular arrhythmias and thromboembolic events leading to increased mortality and morbidity. The clinical presentation varies widely and it’s often difficult to differentiate LVNC from other severe forms of hypertrophic or dilated cardiomyopathy.</p> <p>Aim: To evaluate and characterize a population of patients with LVNC comparing the dilated with the non-dilated phenotype.</p> <p>Methods: Multicenter retrospective study involving 12 hospital centers including 119 patients diagnosed with LVNC. Two groups were formed: Group DL (n=66; 55,5%) with a left ventricle end-diastolic diameter (LVED) > 58mm (men) or >52 mm (women), and a group NDL (n=53; 44,5%) with LVED in the normal range. We evaluated demographic, clinical, electrocardiographic, echocardiographic, cardiac magnetic resonance imaging and follow-up data.</p> <p>Results: The patients in DL group were predominantly of the male gender (74,2%, p<0,001) with less familial history of LVNC (p=0,013) and presented with more symptomatic (NYHA class III/IV p=0,005) heart failure symptoms (p<0,001), mainly dyspnea (p=0,04). The echocardiogram showed depressed left ventricular function as assessed by ejection fraction (EF) (p<0,001) and mitral S wave velocity (septal p=0,005; lateral p<0,001) as well as more diffuse wall motion abnormalities (p<0,003) and elevated left atrial volume (p=0,007). In this population cardiac MRI was consistent with a higher LV Mass (p=0,04) with reduced EF (p<0,001) and with the presence of late gadolinium enhancement at the LV apex (p=0,033) when compared with the NDL group. LBBB was more frequent as assessed by ECG (p=0,01) as well as non-sustained ventricular tachycardia assessed by Holter (p=0,05). There were no differences related to thromboembolic events or prognostic variables between groups.</p> <p>Conclusion: LVNC patients with dilated phenotype are a special subgroup: more symptomatic and with worse LV function, however prognosis seems not be different when compared to LVNC patients with non-dilated left ventricle as assessed by LVED. </p>
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