Login
Search
Search
0 Dates
2024
2023
2022
2021
2020
2019
2018
0 Events
CPC 2018
CPC 2019
Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
CPC 2020
CPC 2021
CPC 2022
CPC 2023
CPC 2024
0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
G. Aortic Disease, Peripheral Vascular Disease, Stroke
H. Interventional Cardiology and Cardiovascular Surgery
I. Hypertension
J. Preventive Cardiology
K. Cardiovascular Disease In Special Populations
L. Cardiovascular Pharmacology
M. Cardiovascular Nursing
N. E-Cardiology / Digital Health, Public Health, Health Economics, Research Methodology
O. Basic Science
P. Other
0 Themes
01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
37. Miscellanea
0 Resources
Abstract
Slides
Vídeo
Report
CLEAR FILTERS
Validation of HMPAO-Tc-99m as a radiotracer for myocardial perfusion – preliminary results
Session:
CO6 - Imagiologia Cardiovascular
Speaker:
Maria Teresa Faria
Congress:
CPC 2019
Topic:
B. Imaging
Theme:
03. Imaging
Subtheme:
03.4 Nuclear Imaging
Session Type:
Comunicações Orais
FP Number:
---
Authors:
Maria Teresa Faria; Maria do Carmo Vilas-Boas; Paulo Manuel Maia; Ana Oliveira; Ricardo Rego; Joel Sousa; Jorge Pereira; J P S Cunha; Francisco Rocha Gonçalves; Elisabete Martins
Abstract
<p><strong>Introduction</strong> – We have previously reported the possibility of imaging the heart with HMPAO-99mTc (HMPAO). Being a brain perfusion radiotracer, mapping of myocardial perfusion seemed also probable, permitting the use of a single radiotracer on patients with epilepsy with less radioactive exposure.</p> <p><strong>Purpose</strong> – To compare myocardial gated SPECT images made with both HMPAO and Tetrofosmin-Tc-99m (Tetrofosmin).</p> <p><strong>Methods</strong> – In three patients who had Tetrofosmin myocardial perfusion scintigraphy (MPS) as part of their clinical evaluation, we acquired myocardial SPECT images with HMPAO. Both studies were acquired in gated mode.</p> <p>We selected another two patients who had ictal brain perfusion SPECT and needed to perform a MPS as well (stress, only). In these cases, we acquired an ictal myocardial SPECT after the brain SPECT (HMPAO).</p> <p>Algorithms were developed in MATLAB R2016 to compare the Tetrofosmin and HMPAO images of each reconstructed plane (short axis - SA -, vertical long axis - VLA -, and horizontal long axis - HLA -). After applying a median filter, each slice pair was aligned and the area of interest was defined. A pixel-wise correlation was calculated for every slice, using Pearson’s Correlation Coefficient.</p> <p>Reversibility of the defects was also evaluated (correlation of the rest-stress subtraction with each radiotracer), as were the polar maps.</p> <p>The study was approved by our Institution Ethics Committee. All patients gave their informed consent.</p> <p><strong>Results</strong> – In the five patients evaluated, we obtained high correlations for perfusion images [better in the VLA, (0.88-0.94, stress), (0.88-0.90, rest)]. Reversibility correlations varied between 0.45 and 0.8 (3 axes). Gated images correlations between each slice of each gate were also better in VLA [mean values: 0.78-0.89 (stress), 0.78-0.84 (rest)]. The polar maps correlations were 0.93-0.96 (stress), 0.93-0.95 (rest) and 0.6-0.9 (reversibility).</p> <p>Patient 2 had poorer correlations due to lung HMPAO uptake, interfering with image processing. That patient has smoking habits (a known cause of HMPAO lung uptake).</p> <p><strong>Conclusion </strong>– We obtained high correlations for cardiac studies between Tetrofosmin and HMPAO, especially in VLA.</p> <p>Myocardial SPECT with HMPAO may be a screening method for myocardial ischemia in non-smoking patients with epilepsy who already need a HMPAO brain perfusion SPECT. In a subset of these patients prone to have heart changes (e.g. those with rises in ictal Troponin I) it could serve as a gateway to MPS.</p>
Our mission: To reduce the burden of cardiovascular disease
Visit our site