Login
Search
Search
0 Dates
2024
2023
2022
2021
2020
2019
2018
0 Events
CPC 2018
CPC 2019
Curso de Atualização em Medicina Cardiovascular 2019
Reunião Anual Conjunta dos Grupos de Estudo de Cirurgia Cardíaca, Doenças Valvulares e Ecocardiografia da SPC
CPC 2020
CPC 2021
CPC 2022
CPC 2023
CPC 2024
0 Topics
A. Basics
B. Imaging
C. Arrhythmias and Device Therapy
D. Heart Failure
E. Coronary Artery Disease, Acute Coronary Syndromes, Acute Cardiac Care
F. Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease
G. Aortic Disease, Peripheral Vascular Disease, Stroke
H. Interventional Cardiology and Cardiovascular Surgery
I. Hypertension
J. Preventive Cardiology
K. Cardiovascular Disease In Special Populations
L. Cardiovascular Pharmacology
M. Cardiovascular Nursing
N. E-Cardiology / Digital Health, Public Health, Health Economics, Research Methodology
O. Basic Science
P. Other
0 Themes
01. History of Cardiology
02. Clinical Skills
03. Imaging
04. Arrhythmias, General
05. Atrial Fibrillation
06. Supraventricular Tachycardia (non-AF)
07. Syncope and Bradycardia
08. Ventricular Arrhythmias and Sudden Cardiac Death (SCD)
09. Device Therapy
10. Chronic Heart Failure
11. Acute Heart Failure
12. Coronary Artery Disease (Chronic)
13. Acute Coronary Syndromes
14. Acute Cardiac Care
15. Valvular Heart Disease
16. Infective Endocarditis
17. Myocardial Disease
18. Pericardial Disease
19. Tumors of the Heart
20. Congenital Heart Disease and Pediatric Cardiology
21. Pulmonary Circulation, Pulmonary Embolism, Right Heart Failure
22. Aortic Disease
23. Peripheral Vascular and Cerebrovascular Disease
24. Stroke
25. Interventional Cardiology
26. Cardiovascular Surgery
27. Hypertension
28. Risk Factors and Prevention
29. Rehabilitation and Sports Cardiology
30. Cardiovascular Disease in Special Populations
31. Pharmacology and Pharmacotherapy
32. Cardiovascular Nursing
33. e-Cardiology / Digital Health
34. Public Health and Health Economics
35. Research Methodology
36. Basic Science
37. Miscellanea
0 Resources
Abstract
Slides
Vídeo
Report
CLEAR FILTERS
Increased plasma homocysteine predicts early atrial fibrillation recurrence after electrical cardioversion
Session:
Posters 1 - Écran 10 - Arritmologia
Speaker:
Daniel Faria
Congress:
CPC 2019
Topic:
C. Arrhythmias and Device Therapy
Theme:
05. Atrial Fibrillation
Subtheme:
05.2 Atrial Fibrillation - Epidemiology, Prognosis, Outcome
Session Type:
Posters
FP Number:
---
Authors:
Daniel Candeias Faria; d. Roque; João Baltazar Ferreira; Hilaryano Ferreira; Marco Beringuilho; Miguel Borges Dos Santos; Francisco Madeira; Nuno Cabanelas; Mariana Faustino; João Augusto
Abstract
<p><strong>Background:</strong></p> <p>Previous studies suggest that inflammatory markers are elevated in patients with atrial fibrillation (AF). The methionine-homocysteine cycle that regulates both methylation reactions and redox balance, known as methoxistasis, is disturbed in various inflammatory states and correlates with poorer outcomes. Plasma homocysteine levels can be used as a general gauge of deviation from methoxistasis and abnormally high levels are related with oxidative stress, inflammation, atrial remodeling and fibrosis.</p> <p> </p> <p><strong>Purpose: </strong></p> <p>To evaluate if elevated plasma homocysteine is a predictor of early AF recurrence after electric cardioversion (EC).</p> <p> </p> <p><strong>Patients and Methods:</strong></p> <p>We prospectively enrolled 57 patients who were submitted to EC for non-permanent AF. Data collected included demographics, clinical characteristics, inflammatory biochemical markers before EC as well as ECG before and after EC. Both transthoracic and transoesophageal echocardiograms were performed prior to EC in all patients. Patients with known chronic systemic inflammatory disease, active infection, cancer, heart failure and coronary artery disease were excluded. The choice of the antiarrhythmic drug after EC was left at the discretion of the attending physician. After EC, patients were routinely monitored with electrocardiogram and 24-hour Holter for AF recurrence for 12 months. Early AF recurrence was defined if occurring until 30 days after EC.</p> <p> </p> <p><strong>Results:</strong></p> <p>A total of 48 patients were included in the final analysis. Mean age was 63.8 <u>+</u> 13.2 years, 54.2% were males. Follow-up was achieved in 93.8% of our population. AF recurred in 46.6% (n=21) and mortality rate was 8.9% (n=4). Serum homocysteine levels were significantly higher in patients with early AF recurrence (22.84 vs 12.82 μmol/L, p<0.0001, Figure 1). Serum homocysteine yielded a good diagnostic performance in predicting early AF recurrence using receiver operating characteristic analysis (area under the curve of 0.869, Figure 2). Using the cut-off of 17.65μmol/L, sensitivity for early AF recurrence was 80% and specificity was 94%. Kaplan-Meier analysis showed a significantly higher early AF recurrence rate in patients with serum homocysteine levels > 17.65μmol/L (75% vs 10% in patients with homocysteine <u><</u> 17.65 μmol/L, log-rank p=0.001).</p> <p> </p> <p><strong>Conclusions:</strong></p> <p>A higher oxidative stress and pro-inflammatory state as reflected by homocysteine levels is associated with early recurrence of AF after electric cardioversion.</p>
Our mission: To reduce the burden of cardiovascular disease
Visit our site